DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sardh and DMGDH

DIOPT Version :9

Sequence 1:NP_611263.1 Gene:Sardh / 37026 FlyBaseID:FBgn0034276 Length:894 Species:Drosophila melanogaster
Sequence 2:NP_037523.2 Gene:DMGDH / 29958 HGNCID:24475 Length:866 Species:Homo sapiens


Alignment Length:865 Identity:267/865 - (30%)
Similarity:426/865 - (49%) Gaps:76/865 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ADVVVIGGGSAGCHTLYHLARRGVK-AVLLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRR 100
            |:.|:||||..|....||||:.|:| .||||:::||||:|||.|||.....|.....::..:|.:
Human    50 AETVIIGGGCVGVSLAYHLAKAGMKDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIK 114

  Fly   101 MLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIENQVLSPEDTQKLFPLLDPS 165
            :.::|||||....|:.|.|.|.:|....|:||::...|.......|..::.||..|::||||:.:
Human   115 LYEKLEEETGQVVGFHQPGSIRLATTPVRVDEFKYQMTRTGWHATEQYLIEPEKIQEMFPLLNMN 179

  Fly   166 AFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIK 230
            ..:..||:||||.:||..|..||...|...||.:.....|..|    .||......|.||.|.::
Human   180 KVLAGLYNPGDGHIDPYSLTMALAAGARKCGALLKYPAPVTSL----KARSDGTWDVETPQGSMR 240

  Fly   231 AEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVSESIPGV----RGLPNIRDHDYSTYFRIQGD 291
            |.::|||.|.|.|::....|...||:|::|.|:|:.:|..|    |.||.:||.:.|.|.|.:.|
Human   241 ANRIVNAAGFWAREVGKMIGLEHPLIPVQHQYVVTSTISEVKALKRELPVLRDLEGSYYLRQERD 305

  Fly   292 AICMGGYE-------PNPILLEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCG 349
            .:..|.||       .:..:...||..|...|:|.|......|::.|.::.|...|..:.:.|.|
Human   306 GLLFGPYESQEKMKVQDSWVTNGVPPGFGKELFESDLDRIMEHIKAAMEMVPVLKKADIINVVNG 370

  Fly   350 PESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQ 414
            |.:::||..|::||...:...:...|| ..|::..||.|:..:.|::.|:|...:...|..|:  
Human   371 PITYSPDILPMVGPHQGVRNYWVAIGF-GYGIIHAGGVGKYLSDWILHGEPPFDLIELDPNRY-- 432

  Fly   415 EQGK--AIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGF 477
              ||  ..|:...|:.|||..|..:.:..::..|||..|:.....:.:::...|....|||:|.:
Human   433 --GKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYQRLESKCSMGFHAGWEQPHW 495

  Fly   478 FLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFN 542
            |...|                    :|::|....       |.:.:.:.:|||.........|.:
Human   496 FYKPG--------------------QDTQYRPSF-------RRTNWFEPVGSEYKQVMQRVAVTD 533

  Fly   543 MSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPK 607
            :|.|.|..:.|..:....|.|| ||.......|..:..|...|.|.|::|:|..:||.       
Human   534 LSPFGKFNIKGQDSIRLLDHLF-ANVIPKVGFTNISHMLTPKGRVYAELTVSHQSPGE------- 590

  Fly   608 INGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLS 672
                 |.::.|..|..:....:..|..:.|::..:|::|.||||:.:.||.:||:||.|...|||
Human   591 -----FLLITGSGSELHDLRWIEEEAVKGGYDVEIKNITDELGVLGVAGPQARKVLQKLTSEDLS 650

  Fly   673 DEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSL 737
            |:......|:..|..::.:..:|:|:.||||:||:..::|..|:|.::|.||..|.:.|.|..::
Human   651 DDVFKFLQTKSLKVSNIPVTAIRISYTGELGWELYHRREDSVALYDAIMNAGQEEGIDNFGTYAM 715

  Fly   738 YSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRLVYLTL-RD 800
            .:|..||.:..|..::..|..||||||.:..: ...||:.||.|::..:|:|||:|||.||| .|
Human   716 NALRLEKAFRAWGLEMNCDTNPLEAGLEYFVKLNKPADFIGKQALKQIKAKGLKRRLVCLTLATD 780

  Fly   801 QVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEVDILGKKY 865
            .|...|.|.::.||:.||......|:|::.|||...||.....::       ..:.||::|||.|
Human   781 DVDPEGNESIWYNGKVVGNTTSGSYSYSIQKSLAFAYVPVQLSEV-------GQQVEVELLGKNY 838

  Fly   866 RADCHLRSPF---DPTGQRV 882
            .| ..::.|.   :||..|:
Human   839 PA-VIIQEPLVLTEPTRNRL 857

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SardhNP_611263.1 DadA 33..412 CDD:223737 129/386 (33%)
NADB_Rossmann 37..>76 CDD:304358 21/39 (54%)
nuc_hydro 203..>281 CDD:294156 29/81 (36%)
FAO_M 398..449 CDD:292961 14/52 (27%)
GcvT 446..884 CDD:223481 129/442 (29%)
GCV_T 456..767 CDD:279857 84/310 (27%)
GCV_T_C 774..867 CDD:285832 35/93 (38%)
DMGDHNP_037523.2 NADB_Rossmann 44..>90 CDD:304358 21/39 (54%)
DadA 47..435 CDD:223737 131/393 (33%)
FAO_M 417..472 CDD:292961 16/58 (28%)
GcvT 464..857 CDD:223481 128/440 (29%)
GCV_T 482..745 CDD:279857 84/302 (28%)
GCV_T_C 753..845 CDD:285832 36/99 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0404
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53337
OrthoDB 1 1.010 - - D96522at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3396
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.860

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