Protein Alignment Sardh and Dmgdh

DIOPT Version :10

• Sequence 1: NP_611263.1
• Gene: Sardh / 37026
• FlyBaseID: FBgn0034276
• Length: 894
• Species: Drosophila melanogaster
• Sequence 2: XP_038957650.1
• Gene: Dmgdh / 245961
• RGDID: 620453
• Length: 884
• Species: Rattus norvegicus
• Alignment Length: 865
• Identity: 265/865 - (30%)
• Similarity: 422/865 - (48%)
• Gaps: 76/865 - (8%)

  Fly    37 ADVVVIGGGSAGCHTLYHLARRGVK-AVLLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRR 100
            |:.|:||||..|....||||:.|:: .||||:::||||:|||.|||.....|.....::..:|.:
  Rat    70 AETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIK 134

  Fly   101 MLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIENQVLSPEDTQKLFPLLDPS 165
            :.::|||||....|:.|.|.|.:|....|:||::...|..:....|..::.||...:|||||:..
  Rat   135 LYERLEEETGQVVGFHQPGSIRLATTPERVDEFKYQMTRTNWHATEQYIIEPEKIHELFPLLNMD 199

  Fly   166 AFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIK 230
            ..:..||:||||.:||..|..||...|...||.:.....|..|    ..|......|.||.|.::
  Rat   200 KILAGLYNPGDGHIDPYSLTMALATGARKYGALLKYPAPVTSL----KPRPDGTWDVETPQGSVR 260

  Fly   231 AEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVSESIPGV----RGLPNIRDHDYSTYFRIQGD 291
            |.::|||.|.|.|::....|...||:|::|.|:::.:||.|    |.||.:||.:.|.|.|.:.|
  Rat   261 ANRIVNAAGFWAREVGKMIGLDHPLIPVQHQYVITSTIPEVKALKRELPVLRDLEGSYYLRQERD 325

  Fly   292 AICMGGYEPNPIL-------LEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCG 349
            .:..|.||....:       ...||..|...|:|.|......|||.|.::.|...|..:.:.|.|
  Rat   326 GLLFGPYESQEKMKLQASWVAHGVPPGFGKELFESDLDRITEHVEAAMEMVPVLKKADIINIVNG 390

  Fly   350 PESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQ 414
            |.:::||..|::||...:...:...|| ..|::..||.|...:.|::.|:|...:...|..|:
  Rat   391 PITYSPDILPMVGPHQGVRNYWVAIGF-GYGIIHAGGVGTYLSDWILHGEPPFDLIELDPNRY-- 452

  Fly   415 EQGK--AIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGF 477
              ||  ..|:...|:.|||..|..:.:..::..|||..|:.....:::::...|....|||:|.:
  Rat   453 --GKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYKILESKCSMGFHAGWEQPHW 515

  Fly   478 FLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFN 542
            |...|                    :|::|....       |.:.:.:.:|||.........|.:
  Rat   516 FYKPG--------------------QDTQYRPSF-------RRTNWFEPVGSEYKQVMQRVGVID 553

  Fly   543 MSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPK 607
            :|.|.|..:.|..:.:..|.| .||.......|..:..|...|.|.|::|:|..:||.
  Rat   554 LSPFGKFNIKGQDSTQLLDHL-CANVIPKVGFTNISHMLTPRGRVYAELTVSHQSPGE------- 610

  Fly   608 INGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLS 672
                 |.::.|..|..:....:.....|.|::..::::|.||||:.:.||.:|::||.|...|||
  Rat   611 -----FLLITGSGSELHDLRWIEEAAVRGGYDVEIRNITDELGVLGVAGPYARRVLQKLTSEDLS 670

  Fly   673 DEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSL 737
            |:......|:..|..|:.:..:|:|:.||||:||:..::|.||:|..:|.||..|.:.|.|..:|
  Rat   671 DDVFKFLQTKSLKISDIPVTAIRISYTGELGWELYHRREDSAALYERIMNAGQEEGIDNFGTYAL 735

  Fly   738 YSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRLVYLTL-RD 800
            .:|..||.:..|..::..|..||||||.:..: ...|::.||.|::..:|:|||:|||.||| .|
  Rat   736 NALRLEKAFRAWGSEMNCDTNPLEAGLDYFIKLNKPANFTGKQALKQIKAKGLKRRLVCLTLATD 800

  Fly   801 QVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEVDILGKKY 865
            .|...|.|.|:..|:.:|......|:|::.|||...||.....::       ..:.||::|||.|
  Rat   801 NVDPEGNESVWYKGKVIGNTTSGSYSYSIQKSLAFAYVPVELSEV-------GQQVEVELLGKNY 858

  Fly   866 RADCHLRSPF---DPTGQRV 882
            .|.. ::.|.   :||..|:
  Rat   859 PATI-IQEPLVLTEPTRTRL 877

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	37..411	CDD:440429	129/385 (34%)
		FAO_M	398..450	CDD:465100	15/53 (28%)
		GcvT	447..882	CDD:440173	125/439 (28%)
Dmgdh	XP_038957650.1	DadA	69..451	CDD:440429	129/385 (34%)
		FAO_M	437..492	CDD:465100	16/58 (28%)
		GcvT	508..877	CDD:440173	121/416 (29%)