DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sardh and Dmgdh

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_038957650.1	Gene:	Dmgdh / 245961	RGDID:	620453	Length:	884	Species:	Rattus norvegicus

Alignment Length:	865	Identity:	265/865 - (30%)
Similarity:	422/865 - (48%)	Gaps:	76/865 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ADVVVIGGGSAGCHTLYHLARRGVK-AVLLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRR 100
            |:.|:||||..|....||||:.|:: .||||:::||||:|||.|||.....|.....::..:|.:
  Rat    70 AETVIIGGGCVGVSLAYHLAKAGMRDVVLLEKSELTAGSTWHAAGLTTYFHPGINLKKIHYDSIK 134

  Fly   101 MLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIENQVLSPEDTQKLFPLLDPS 165
            :.::|||||....|:.|.|.|.:|....|:||::...|..:....|..::.||...:|||||:..
  Rat   135 LYERLEEETGQVVGFHQPGSIRLATTPERVDEFKYQMTRTNWHATEQYIIEPEKIHELFPLLNMD 199

  Fly   166 AFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIK 230
            ..:..||:||||.:||..|..||...|...||.:.....|..|    ..|......|.||.|.::
  Rat   200 KILAGLYNPGDGHIDPYSLTMALATGARKYGALLKYPAPVTSL----KPRPDGTWDVETPQGSVR 260

  Fly   231 AEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVSESIPGV----RGLPNIRDHDYSTYFRIQGD 291
            |.::|||.|.|.|::....|...||:|::|.|:::.:||.|    |.||.:||.:.|.|.|.:.|
  Rat   261 ANRIVNAAGFWAREVGKMIGLDHPLIPVQHQYVITSTIPEVKALKRELPVLRDLEGSYYLRQERD 325

  Fly   292 AICMGGYEPNPIL-------LEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCG 349
            .:..|.||....:       ...||..|...|:|.|......|||.|.::.|...|..:.:.|.|
  Rat   326 GLLFGPYESQEKMKLQASWVAHGVPPGFGKELFESDLDRITEHVEAAMEMVPVLKKADIINIVNG 390

  Fly   350 PESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQ 414
            |.:::||..|::||...:...:...|| ..|::..||.|...:.|::.|:|...:...|..|:
  Rat   391 PITYSPDILPMVGPHQGVRNYWVAIGF-GYGIIHAGGVGTYLSDWILHGEPPFDLIELDPNRY-- 452

  Fly   415 EQGK--AIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGF 477
              ||  ..|:...|:.|||..|..:.:..::..|||..|:.....:::::...|....|||:|.:
  Rat   453 --GKWTTTQYTEAKARESYGFNNIVGYPKEERFAGRPTQRVSGLYKILESKCSMGFHAGWEQPHW 515

  Fly   478 FLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFN 542
            |...|                    :|::|....       |.:.:.:.:|||.........|.:
  Rat   516 FYKPG--------------------QDTQYRPSF-------RRTNWFEPVGSEYKQVMQRVGVID 553

  Fly   543 MSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPK 607
            :|.|.|..:.|..:.:..|.| .||.......|..:..|...|.|.|::|:|..:||.
  Rat   554 LSPFGKFNIKGQDSTQLLDHL-CANVIPKVGFTNISHMLTPRGRVYAELTVSHQSPGE------- 610

  Fly   608 INGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLS 672
                 |.::.|..|..:....:.....|.|::..::::|.||||:.:.||.:|::||.|...|||
  Rat   611 -----FLLITGSGSELHDLRWIEEAAVRGGYDVEIRNITDELGVLGVAGPYARRVLQKLTSEDLS 670

  Fly   673 DEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSL 737
            |:......|:..|..|:.:..:|:|:.||||:||:..::|.||:|..:|.||..|.:.|.|..:|
  Rat   671 DDVFKFLQTKSLKISDIPVTAIRISYTGELGWELYHRREDSAALYERIMNAGQEEGIDNFGTYAL 735

  Fly   738 YSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRLVYLTL-RD 800
            .:|..||.:..|..::..|..||||||.:..: ...|::.||.|::..:|:|||:|||.||| .|
  Rat   736 NALRLEKAFRAWGSEMNCDTNPLEAGLDYFIKLNKPANFTGKQALKQIKAKGLKRRLVCLTLATD 800

  Fly   801 QVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEVDILGKKY 865
            .|...|.|.|:..|:.:|......|:|::.|||...||.....::       ..:.||::|||.|
  Rat   801 NVDPEGNESVWYKGKVIGNTTSGSYSYSIQKSLAFAYVPVELSEV-------GQQVEVELLGKNY 858

  Fly   866 RADCHLRSPF---DPTGQRV 882
            .|.. ::.|.   :||..|:
  Rat   859 PATI-IQEPLVLTEPTRTRL 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	129/386 (33%)
		NADB_Rossmann	37..>76	CDD:304358	20/39 (51%)
		nuc_hydro	203..>281	CDD:294156	28/81 (35%)
		FAO_M	398..449	CDD:292961	14/52 (27%)
		GcvT	446..884	CDD:223481	127/442 (29%)
		GCV_T	456..767	CDD:279857	84/310 (27%)
		GCV_T_C	774..867	CDD:285832	33/93 (35%)
Dmgdh	XP_038957650.1	DadA	67..455	CDD:223737	131/393 (33%)
		FAO_M	437..492	CDD:406692	16/58 (28%)
		GcvT	508..877	CDD:223481	121/416 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53337
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830