DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sardh and SARDH

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_001128179.1	Gene:	SARDH / 1757	HGNCID:	10536	Length:	918	Species:	Homo sapiens

Alignment Length:	884	Identity:	451/884 - (51%)
Similarity:	600/884 - (67%)	Gaps:	13/884 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 QQASRRGISKQVREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRGVK-AVLLERAQLT 71
            |:..:.|....|...|     ||..||..|:||||||||.||.||||||:.|:. ||||||.:||
Human    43 QRTLKEGQGTSVVAQG-----PSRPLPSTANVVVIGGGSLGCQTLYHLAKLGMSGAVLLERERLT 102

  Fly    72 AGTTWHTAGLLWRLRPNDVDIQLLANSRRML-QQLEEETELDPGWIQNGGIFIAHNETRLDEYRR 135
            :|||||||||||:|||:||:::|||::||:: ::|||||.|..|||||||:|||.|..|||||:|
Human   103 SGTTWHTAGLLWQLRPSDVEVELLAHTRRVVSRELEEETGLHTGWIQNGGLFIASNRQRLDEYKR 167

  Fly   136 LATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVI 200
            |.::|.|.|:|:.||||.:|:.|:||::.....|.||.|.||.||||..|..|.:||:..|||||
Human   168 LMSLGKAYGVESHVLSPAETKTLYPLMNVDDLYGTLYVPHDGTMDPAGTCTTLARAASARGAQVI 232

  Fly   201 ENCGVDDLLLEQTARG-KKVVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIV 264
            |||.|..:.:.....| ::|.||.|..|.|:...|||..|||...:....|..:|||.|.|||:|
Human   233 ENCPVTGIRVWTDDFGVRRVAGVETQHGSIQTPCVVNCAGVWASAVGRMAGVKVPLVAMHHAYVV 297

  Fly   265 SESIPGVRGLPNIRDHDYSTYFRIQGDAICMGGYEPNPILLEPVPKDFHFGLYELDWSVFETHVE 329
            :|.|.|::.:||:||||.|.|.|:||||:.:||||.|||..|.|...|.|||::|||.||..|:|
Human   298 TERIEGIQNMPNVRDHDASVYLRLQGDALSVGGYEANPIFWEEVSDKFAFGLFDLDWEVFTQHIE 362

  Fly   330 GAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALW 394
            ||....|...|.|:|||||||||||||||||||..|.|.|.:..|||||||||.|||||::.|.|
Human   363 GAINRVPVLEKTGIKSTVCGPESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHW 427

  Fly   395 VIQGQPDLPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEM 459
            :|.|:|:..|.|:|:|||........:||||:|||||.||||:||.:|:|||||:.::||||:|:
Human   428 IIHGRPEKDMHGYDIRRFHHSLTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEEL 492

  Fly   460 MKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYH 524
            :..|.|.:|:.||||||:|.|.|  .|.|..||:||:|..:.|:|..|.|:| .|.:...|..:|
Human   493 LGQGCVFQERHGWERPGWFHPRG--PAPVLEYDYYGAYGSRAHEDYAYRRLL-ADEYTFAFPPHH 554

  Fly   525 DLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEA 589
            |.|..|.||||..|.||:||||.|..|.|..|::||||||||:.:|.|..|||||.||..||.|:
Human   555 DTIKKECLACRGAAAVFDMSYFGKFYLVGLDARKAADWLFSADVSRPPGSTVYTCMLNHRGGTES 619

  Fly   590 DVTISRLAPG-SGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVIS 653
            |:|:|||||. ......|...|.|:|:..|||.|.:.:|.:...::.:.....|.|.:.:||:||
Human   620 DLTVSRLAPSHQASPLAPAFEGDGYYLAMGGAVAQHNWSHITTVLQDQKSQCQLIDSSEDLGMIS 684

  Fly   654 IQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYR 718
            ||||.||.|||.::|.|||:|....::.:|.:.....:|.:|:|||||||:|||:||..|..|||
Human   685 IQGPASRAILQEVLDADLSNEAFPFSTHKLLRAAGHLVRAMRLSFVGELGWELHIPKASCVPVYR 749

  Fly   719 SLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIE 782
            ::|.|||...|.|||||::.|||.||||..|..||||||:||||||.|||: |:...:.|:.|:|
Human   750 AVMAAGAKHGLINAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSPVPFLGREALE 814

  Fly   783 NQRAEGLKKRLVYLTLRDQVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIID 847
            .|||.||::|||..|:.|:||::|||.::|||:.||.:|||::.:.:.|::...|:..|.|..:.
Human   815 QQRAAGLRRRLVCFTMEDKVPMFGLEAIWRNGQVVGHVRRADFGFAIDKTIAYGYIHDPSGGPVS 879

  Fly   848 ADYIRNGEYEVDILGKKYRADCHLRSPFDPTGQRVLGNY 886
            .|::::|:|.::.:|..|.|..||:|||||..:||.|.|
Human   880 LDFVKSGDYALERMGVTYGAQAHLKSPFDPNNKRVKGIY 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	216/381 (57%)
		NADB_Rossmann	37..>76	CDD:304358	28/39 (72%)
		nuc_hydro	203..>281	CDD:294156	31/78 (40%)
		FAO_M	398..449	CDD:292961	28/50 (56%)
		GcvT	446..884	CDD:223481	207/439 (47%)
		GCV_T	456..767	CDD:279857	152/311 (49%)
		GCV_T_C	774..867	CDD:285832	35/92 (38%)
SARDH	NP_001128179.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40
		DadA	63..447	CDD:223737	218/383 (57%)
		FAO_M	430..485	CDD:292961	29/54 (54%)
		GcvT	479..916	CDD:223481	207/439 (47%)
		GCV_T	489..798	CDD:279857	152/311 (49%)
		GCV_T_C	807..>871	CDD:285832	28/63 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159361
Domainoid	1	1.000	418	1.000	Domainoid score	I646
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5149
Inparanoid	1	1.050	901	1.000	Inparanoid score	I383
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53337
OrthoDB	1	1.010	-	-		D813396at2759
OrthoFinder	1	1.000	-	-		FOG0008062
OrthoInspector	1	1.000	-	-		oto89940
orthoMCL	1	0.900	-	-		OOG6_107060
Panther	1	1.100	-	-	LDO	PTHR13847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6012
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770