DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sardh and pdpr-1

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_492730.2	Gene:	pdpr-1 / 172922	WormBaseID:	WBGene00013718	Length:	855	Species:	Caenorhabditis elegans

Alignment Length:	895	Identity:	247/895 - (27%)
Similarity:	388/895 - (43%)	Gaps:	129/895 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ADVVVIGGGSAGCHTLYHLARRGVKAVLLERAQL-TAGTTWHTAGLL-----WRLRPNDVDIQLL 95
            |||||.|||.:|....||||:||.|..|:|:..: .:|.|..:|||:     |:    |..:|.:
Worm    22 ADVVVCGGGISGTSIAYHLAKRGKKVALVEKDSIGCSGATGLSAGLVSSPIFWQ----DTSLQAI 82

  Fly    96 ANSRRMLQQLEEETELDPGWIQNGGIFIAH---NETRLDEYRRLATVGSALGIENQVLSPEDTQ- 156
            |.:...|.. ...|.....:|:.|..::|.   ||..|   ||:.:.|.   :.|..:...|.|
Worm    83 AQASLDLYS-HLATTCKFRYIKCGRTYLASSMANEILL---RRMYSRGV---VHNDKVELLDCQS 140

  Fly   157 ---KLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARGKK 218
               :.:|.|.......||:||.|..:||..||..|...|.:.||.:.|:   :.:|.......|:
Worm   141 EMLERWPFLQTEDVQLALFSPEDVALDPVALCQHLALIAKDYGALIYES---NPVLEVHIGDEKQ 202

  Fly   219 VVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHL-----------PLVPMKHAYIVSESIP--G 270
            |.||||..|.|:....|:|.|:|.       |:||           ...|..::||.:..:|  .
Worm   203 VYGVSTKMGFIETSHFVDAAGIWA-------GSHLVKALPHQHVQTAAYPCTYSYIHTSKLPTGS 260

  Fly   271 VRGL-PNIRDHDYSTYFRIQG-DAICMGGYEPNPILLEPVPKDF-------HFGLYELDWSVFET 326
            |..: |...|.|.:...|... ..:|.|..|.:   :.|:.:..       |   .|.||:.|:.
Worm   261 VSDMTPIFNDLDGNVMLRTTSFKTLCAGFAEES---IRPLARQTGSATPWQH---PEPDWNTFDP 319

  Fly   327 HVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQT 391
            ::|.....||..........:.|.|::|||..|.:|......|.:..||.|..|:...||.|:..
Worm   320 NLEKLISRCPMLGDCNHGDLIVGMEAYTPDKLPTIGESSQAKGYWVMCGMNGQGLSLAGGLGKIL 384

  Fly   392 ALWVIQGQPD-LPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPL 455
            ...:.:.|.. ..:...|:.||....... |::..::.|.....||.::...|....|:.:..|:
Worm   385 GELMCESQSSTADVARVDVGRFIDLHANN-QYLIGRTPEVAALTYSNLYHSHQCHTARNLRMAPI 448

  Fly   456 HDEMMKAGAVMEEKQGWERPGFF--LPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYS 518
            :.::..||||..|..|:|||.:|  .|...:.|::...|                 .|.|.
Worm   449 YHQLRDAGAVFGEIMGYERPLWFEKTPKTERNALMSGQD-----------------ALIGK---- 492

  Fly   519 RFSEYHDLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALND 583
              .|:.:.:.||..|||....:.:||.|:|..:.|..|.|...:|.|||.:.....||||...:.
Worm   493 --PEWFERVASEYEACRERVGLMDMSSFSKYDITGEDAVEYLQFLCSANVDEPIGTTVYTGMQHQ 555

  Fly   584 AGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLK----- 643
            .||...|.|:|||    ||        :.|::|   |.......||   :..|.:.|.||
Worm   556 KGGYVTDCTLSRL----GE--------KKFFMV---APTIQQERVL---VWMKKWQAILKARVHV 602

  Fly   644 -DLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFG-DVGLRLLRVSFVGELGYEL 706
             |:|.....:.:.||:||.::..:....:|.........:....| ..|:|.:.|:..||||:.:
Worm   603 QDVTGAYTALDLIGPSSRYLMGDITGLSMSSNDFPTFRCQEINIGMATGIRAISVTHCGELGWVI 667

  Fly   707 HVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTC--R 769
            :||.:....||..::.||....|::|||.:|..|..||.|..|..|:....||:|.|..|..  :
Worm   668 YVPNEVAQNVYEKILDAGKEYSLQHAGYYTLRQLRIEKFYVYWGQDINATVTPVECGRLFRVDFK 732

  Fly   770 KTGADYRGKAAIENQRAEGLKKRLVYLTL----RDQVPIW--GLEGVYRNGEPVGILRRAEYAYT 828
            |   |:.||.|:|.|...|:.||.|.|.:    ::..| |  |.|.:.::|..||:...|.|.:|
Worm   733 K---DFIGKKALEEQVERGVSKRFVQLLVDGHDKETDP-WPQGGETILKDGRAVGLTTSAAYGFT 793

  Fly   829 LGKSLGQTYVSRPD-GKIIDADYIRNGEYEVDILGKKYRADCHLRSPFDP 877
            ||..:...||...: |  :..:::.:|.:|:||.||::....::.||..|
Worm   794 LGCQVCIGYVENKEFG--VSPEFVSSGHFEIDIAGKRFTCRLNVHSPSLP 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	111/410 (27%)
		NADB_Rossmann	37..>76	CDD:304358	19/39 (49%)
		nuc_hydro	203..>281	CDD:294156	23/91 (25%)
		FAO_M	398..449	CDD:292961	9/51 (18%)
		GcvT	446..884	CDD:223481	129/450 (29%)
		GCV_T	456..767	CDD:279857	90/319 (28%)
		GCV_T_C	774..867	CDD:285832	32/99 (32%)
pdpr-1	NP_492730.2	DAO	23..387	CDD:279590	108/390 (28%)
		NAD_binding_8	28..>54	CDD:290186	13/25 (52%)
		FAO_M	394..445	CDD:292961	9/51 (18%)
		GcvT	439..833	CDD:223481	126/440 (29%)
		GCV_T	449..724	CDD:279857	89/315 (28%)
		GCV_T_C	733..833	CDD:285832	33/105 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820