DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sardh and Sardh

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	NP_446116.1	Gene:	Sardh / 114123	RGDID:	621125	Length:	919	Species:	Rattus norvegicus

Alignment Length:	863	Identity:	449/863 - (52%)
Similarity:	595/863 - (68%)	Gaps:	8/863 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PSGFLPGAADVVVIGGGSAGCHTLYHLARRGV-KAVLLERAQLTAGTTWHTAGLLWRLRPNDVDI 92
            ||..||..|:||||||||.||.||||||:.|| ..|||||.:||:|||||||||||:|||:||::
  Rat    60 PSQPLPSTANVVVIGGGSLGCQTLYHLAKLGVGGVVLLERERLTSGTTWHTAGLLWQLRPSDVEV 124

  Fly    93 QLLANSRRML-QQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIENQVLSPEDTQ 156
            :|||::|::: ..|||||.|..|||||||:|||.|:.|||||:||.::|.|.|||:.||||.:|:
  Rat   125 ELLAHTRQVVSHDLEEETGLHTGWIQNGGLFIASNQQRLDEYKRLMSLGKAYGIESHVLSPAETK 189

  Fly   157 KLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARG-KKVV 220
            .|:||::.....|.||.|.||.||||..|..|.:||...||||||||.|..:.:.....| ::|.
  Rat   190 DLYPLMNVDDLYGTLYVPRDGTMDPAGTCTTLTRAAVARGAQVIENCAVTGIRVRTDDFGVRRVT 254

  Fly   221 GVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVSESIPGVRGLPNIRDHDYSTY 285
            .|.|..|.|:...|||..|||...:....|..:|||.|.|||:|:|.|.|::.:||:||||.|.|
  Rat   255 AVETQHGSIQTPCVVNCAGVWASSVGRMAGVKVPLVAMHHAYVVTERIEGIQNMPNVRDHDASVY 319

  Fly   286 FRIQGDAICMGGYEPNPILLEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCGP 350
            .|:||||:.:||||.|||..:.|...|.|||::|||.||..|:|||....|...|.|:|||||||
  Rat   320 LRLQGDALSVGGYEANPIFWDEVSDKFAFGLFDLDWDVFTQHIEGAINRVPVLEKTGIKSTVCGP 384

  Fly   351 ESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQE 415
            ||||||||||||..|.|.|.:..|||||||||.|||||::.|.|::.|:|:..|:.:|:|||...
  Rat   385 ESFTPDHKPLMGEAPELRGFFLGCGFNSAGMMLGGGCGQELAHWIVHGRPEKDMYSYDIRRFHHS 449

  Fly   416 QGKAIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLP 480
            .....:||||:|||||.||||:||.:|:|||||:.::||||:|::..|.|.:|:|||||||:|.|
  Rat   450 LTDHPRWIRERSHESYAKNYSVVFPHDEPLAGRNMRRDPLHEELLGQGCVFQERQGWERPGWFNP 514

  Fly   481 TGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFNMSY 545
              .:.|.|..||:||:|.||.|||..|.|:| ||.:...|..:|.:|..|.||||..|.||||||
  Rat   515 --QETAQVLDYDYYGAYGHQAHKDYAYSRLL-GDEYTFDFPPHHCVIQKECLACRTAAAVFNMSY 576

  Fly   546 FAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGS-GEVYNPKIN 609
            |.|..|.|..|::|.||||||:.||.|..|||||.||..||.|:|:|:|.||||: .....|...
  Rat   577 FGKFYLLGADARKAPDWLFSADVNRPPGSTVYTCMLNQRGGTESDLTVSCLAPGAQASPLAPAFE 641

  Fly   610 GQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQPLIDCDLSDE 674
            |.|:|:..|||.|.:.:|.:...::.:.|...|.|.:.:||::|||||.||.|||.::|.|||:|
  Rat   642 GDGYYLAVGGAVAQHNWSHINTVLQDQEFRCQLMDCSEDLGMLSIQGPASRDILQDVLDADLSNE 706

  Fly   675 HVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYS 739
            ....::.:|.:.....:|.:|:|||||||:|||||:..|..|||::|.|||...|.|||||::.|
  Rat   707 AFPFSTHQLVRAAGHLVRAIRLSFVGELGWELHVPQASCLPVYRAVMAAGAKHGLVNAGYRAIDS 771

  Fly   740 LSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRLVYLTLRDQVP 803
            ||.||||..|..|||.||:||||||.|||: ||...:.|:.|:|.|||.||::|||.||:.::||
  Rat   772 LSIEKGYRHWHADLRSDDSPLEAGLAFTCKLKTSVPFLGREALEKQRATGLRRRLVCLTVEEEVP 836

  Fly   804 IWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEVDILGKKYRAD 868
            ::|||.::|||:.||.:|||::.:|:.|::...|:..|.|..:..|:::||:|.::.:|..|.|.
  Rat   837 MFGLEAIWRNGQVVGHVRRADFGFTVNKTIAYGYIRDPSGGPVSLDFVKNGDYALERMGVTYAAQ 901

  Fly   869 CHLRSPFDPTGQRVLGNY 886
            .||:|||||..:||.|.|
  Rat   902 VHLKSPFDPDNKRVKGIY 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	212/381 (56%)
		NADB_Rossmann	37..>76	CDD:304358	28/39 (72%)
		nuc_hydro	203..>281	CDD:294156	30/78 (38%)
		FAO_M	398..449	CDD:292961	27/50 (54%)
		GcvT	446..884	CDD:223481	213/439 (49%)
		GCV_T	456..767	CDD:279857	155/311 (50%)
		GCV_T_C	774..867	CDD:285832	37/92 (40%)
Sardh	NP_446116.1	DadA	64..448	CDD:223737	214/386 (55%)
		FAO_M	431..486	CDD:292961	28/54 (52%)
		GcvT	480..917	CDD:223481	211/438 (48%)
		GCV_T	490..799	CDD:279857	154/309 (50%)
		GCV_T_C	808..>872	CDD:285832	29/63 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353389
Domainoid	1	1.000	413	1.000	Domainoid score	I650
eggNOG	1	0.900	-	-		E1_COG0404
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5149
Inparanoid	1	1.050	906	1.000	Inparanoid score	I354
OMA	1	1.010	-	-		QHG53337
OrthoDB	1	1.010	-	-		D813396at2759
OrthoFinder	1	1.000	-	-		FOG0008062
OrthoInspector	1	1.000	-	-		oto97056
orthoMCL	1	0.900	-	-		OOG6_107060
Panther	1	1.100	-	-	LDO	PTHR13847
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6012
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770