DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sardh and pdpr

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_002931709.2	Gene:	pdpr / 100492638	XenbaseID:	XB-GENE-5791461	Length:	865	Species:	Xenopus tropicalis

Alignment Length:	873	Identity:	261/873 - (29%)
Similarity:	412/873 - (47%)	Gaps:	89/873 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 LPGAADVVVIGGGSAGCHTLYHLARRGVKAV-LLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLA 96
            ||..|.||:.|||..|....|||::.|...| |||:.:|.||:|...||::..::...::.::..
Frog    35 LPPRAQVVICGGGIMGASVAYHLSKLGWHDVLLLEQGRLAAGSTRFCAGMVSTIKHISIETEMAD 99

  Fly    97 NSRRMLQQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIENQVLSPEDTQKLFPL 161
            .|.::.||||.||.:..|:.:.|.|.:|..:.||...:|:.:.....||..::::|:...:|.||
Frog   100 YSNKLYQQLEGETGVATGYKKMGSITLAQTQDRLISLKRIVSRLRMKGIPCEIITPKHVAELHPL 164

  Fly   162 LDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLEQTARGKKVVGVSTPF 226
            ::....|||:|.|.|.|:..|.:..||..||...|.:|.|:..|:.:|:|:    ..|.||.|..
Frog   165 INIHDLVGAMYVPDDAVVSTADVTLALVNAAQQKGVKVHEHTTVNHVLVEK----GHVSGVDTDR 225

  Fly   227 GDIKAEKVVNATGVWGRDLVARHGT--HLPLVPMKHAYIVSESI--PGVRGLPNIRDHDYSTYFR 287
            |.::.|..||..|.|..:|...:.:  .:||...:|.|::::.:  |....:|.:.|.|...|.|
Frog   226 GQVECEYFVNCAGQWAYELGLSNESPVSIPLHACEHFYLLTQPLQHPLEDNVPTVVDPDGRIYIR 290

  Fly   288 IQGDAICMGGYEPNPILLEPVPKDFHFGLYEL-------DWSVFETHVEGAQKLCPSYAKYGVKS 345
            .....|..||:|.||   :|:   |..|..:|       ||..||..:....:..||.....:..
Frog   291 NWQGGILSGGFEKNP---KPI---FTEGRNQLEIQNLQEDWDHFEPLLTALLRRMPSLEALEILR 349

  Fly   346 TVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLR 410
            .|..||:||||.:.:||..|.|...:...|.||.|...|||.|:..|.|::.|.|...::..|::
Frog   350 LVNCPEAFTPDMRCVMGESPTLLHYFTLAGMNSQGCSLGGGAGKFLAEWMVFGYPQDNVWPLDIK 414

  Fly   411 RFTQEQGKAIQWIREKSHESYVKNYSM-VFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQGWER 474
            ||...|... .::|.:..|.....|.: |.::|.. .||..:..||:|.:...||...||.|:||
Frog   415 RFGALQSSR-TFLRHRVMEVMPLIYDLKVPRWDFQ-TGRQLRTSPLYDRLDAQGARWMEKHGFER 477

  Fly   475 PGFFLPTG-------SKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEAL 532
            ..:|:|.|       ..|...:| ||:                              |::|||..
Frog   478 AKYFVPPGKDLLALDQSKTFYKP-DWF------------------------------DIVGSEVK 511

  Fly   533 ACRNNAVVFNMSYFAKLLLDGP--QAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISR 595
            .|:....|.:||.|.|..:..|  ||.:...:|||.:.:......|:|..||:.||.|.|.:|.|
Frog   512 CCKEAVCVIDMSSFTKFEISSPGEQALDTLQYLFSNDLDVPVGHIVHTGMLNERGGYENDCSIVR 576

  Fly   596 LAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSR 660
            |            |.:.|::::......:.:|.|...:.... :..|:|:|.:...:::.||.:.
Frog   577 L------------NKRSFFMISPTDQQVHCWSWLRQHMPSDS-DLFLEDVTWKYTALNLIGPRAV 628

  Fly   661 KILQPLIDCDLSDEHVAPNSTRLAKFGDV-GLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAG 724
            .:|..|....::.||......:....|.. |:|::.::..||.|:.|::|.:....||..||..|
Frog   629 DVLSELSYAPMTSEHFPSLFCKEMSVGYANGIRVMSMTHTGEPGFTLYIPIEYALHVYNELMSVG 693

  Fly   725 AGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEG 788
            ....:|||||.:|.||..||.:..|..||....||||.|..|..: ..|.|:.|:.|:..||.||
Frog   694 QKYGIRNAGYYALRSLRIEKFFAFWGQDLDAFTTPLECGREFRVKLDKGYDFIGREALLKQREEG 758

  Fly   789 LKKRLVYLTLRDQ------VPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIID 847
            :.||.....|.|.      .|.|| |.:|||||.||....:.|:||||:.:...:: ..:.:.|.
Frog   759 IFKRFTMFILEDHDTDLDLWPWWG-EPIYRNGEHVGKTTSSAYSYTLGRHVCLGFI-HSNQQPIT 821

  Fly   848 ADYIRNGEYEVDILGKKYRADCHLRSPF 875
            .::|..|||.:||..:|::|...| .||
Frog   822 PEFINRGEYHIDIASQKFKAKAKL-YPF 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	122/390 (31%)
		NADB_Rossmann	37..>76	CDD:304358	18/39 (46%)
		nuc_hydro	203..>281	CDD:294156	21/81 (26%)
		FAO_M	398..449	CDD:292961	12/51 (24%)
		GcvT	446..884	CDD:223481	131/447 (29%)
		GCV_T	456..767	CDD:279857	86/320 (27%)
		GCV_T_C	774..867	CDD:285832	35/98 (36%)
pdpr	XP_002931709.2	DadA	35..422	CDD:223737	125/396 (32%)
pdpr	XP_002931709.2	GcvT	449..813	CDD:223481	119/408 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010