DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sardh and sardh

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_031747425.1	Gene:	sardh / 100492087	XenbaseID:	XB-GENE-6038613	Length:	911	Species:	Xenopus tropicalis

Alignment Length:	873	Identity:	439/873 - (50%)
Similarity:	608/873 - (69%)	Gaps:	8/873 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VREDGGARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRGV-KAVLLERAQLTAGTTWHTAGLL 82
            ::|:..|...|:..||.:||||||||||.||.|.||||:.|| ..|||||.:||:||||||||||
Frog    42 LKEERSAGTGPTKPLPRSADVVVIGGGSLGCQTTYHLAKMGVTNVVLLERDRLTSGTTWHTAGLL 106

  Fly    83 WRLRPNDVDIQLLANSRRML-QQLEEETELDPGWIQNGGIFIAHNETRLDEYRRLATVGSALGIE 146
            |:|||:||:::|||::|.:: ::||:||.|..|||:|||:|||.|:.|||||:||.::|...|:|
Frog   107 WQLRPSDVEVELLAHTRDVVSRELEQETGLHTGWIENGGLFIASNKQRLDEYKRLMSLGKVYGVE 171

  Fly   147 NQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAATNLGAQVIENCGVDDLLLE 211
            :.||||..|:.|:||::.....|.||.|.||.||||..|..|.:|::..||||||||.|..:.::
Frog   172 SYVLSPAQTKDLYPLMNVDDLYGTLYVPKDGTMDPAGTCTTLARASSARGAQVIENCPVTGIRVK 236

  Fly   212 QTARG-KKVVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPMKHAYIVSESIPGVRGLP 275
            ....| ::||.|.|..|.::...|||..|.|...|....|.::|||.|.|||:|:|.|.|::.:|
Frog   237 TDDLGVRRVVAVETLHGTVETPCVVNCAGAWAPKLGQMAGVNVPLVAMHHAYVVTERIEGIQNMP 301

  Fly   276 NIRDHDYSTYFRIQGDAICMGGYEPNPILLEPVPKDFHFGLYELDWSVFETHVEGAQKLCPSYAK 340
            |:||||.|.|.|:||||:.:||||.|||..|.|...|.|||::|||.||..|::||....|:..:
Frog   302 NVRDHDASVYLRLQGDALSVGGYESNPIFWEKVSDKFAFGLFDLDWDVFIQHIQGAINRVPALEQ 366

  Fly   341 YGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFNSAGMMFGGGCGEQTALWVIQGQPDLPMF 405
            .|:|||||||||||.|||||:|..|.:.|.:..|||||||||.|||||::.|.|:|.|:|:..|:
Frog   367 TGIKSTVCGPESFTADHKPLLGESPEVRGFFLGCGFNSAGMMLGGGCGKELAHWIIHGRPEKDMY 431

  Fly   406 GFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYDQPLAGRDFQKDPLHDEMMKAGAVMEEKQ 470
            |:|:|||.:......:||||:|||||.||||:||.||:|||||:.:|||||:|::..|.|.:|:.
Frog   432 GYDIRRFHRSLTNHNRWIRERSHESYAKNYSVVFAYDEPLAGRNMRKDPLHEELLGQGCVFQERH 496

  Fly   471 GWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEYERVLDGDLHYSRFSEYHDLIGSEALACR 535
            ||||||:|.|.|  .|.|..||:||:|..:.|::.:|.|:| |..:...|..:||:|..|.|.||
Frog   497 GWERPGWFNPEG--PAPVLDYDYYGAYGLEPHQEYQYSRLL-GKEYTFNFPPHHDVIRRECLMCR 558

  Fly   536 NNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDPSKTVYTCALNDAGGVEADVTISRLAPGS 600
            |.|.|||||||.|..|.||.|::||:|||:|:.|:.|..|||||.||..||.|:|:|:|.|.||:
Frog   559 NQAAVFNMSYFGKFYLLGPDAKKAANWLFTADINKPPGTTVYTCMLNKQGGAESDLTVSCLEPGT 623

  Fly   601 -GEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKGFNASLKDLTAELGVISIQGPNSRKILQ 664
             |....|:..|:|:|:..|||.|.:.:|.:...::.:.|:..|.|.:.:.|:||||||.||.|||
Frog   624 GGSDLAPQFEGEGYYLAIGGAVAQHNWSHISTVLQDEKFDCKLVDSSEDQGMISIQGPASRTILQ 688

  Fly   665 PLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGELGYELHVPKKDCAAVYRSLMKAGAGEDL 729
            .::|.|||:|....::.:|.......:|.:|:|||||:|:|||:|::.|..||:::|.|||...:
Frog   689 EVLDEDLSNEAFPFSTHKLVTAAGFTVRAIRLSFVGEMGWELHMPREACVPVYKAVMAAGAKHGM 753

  Fly   730 RNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFTCR-KTGADYRGKAAIENQRAEGLKKRL 793
            .|||||::.|||.||||..|..||||||:||||||.|||: |:...:.|:.|:|.|:|.||||||
Frog   754 GNAGYRAIDSLSIEKGYRHWHADLRPDDSPLEAGLAFTCKLKSAIPFLGRGALERQKALGLKKRL 818

  Fly   794 VYLTLRDQVPIWGLEGVYRNGEPVGILRRAEYAYTLGKSLGQTYVSRPDGKIIDADYIRNGEYEV 858
            |..||.::||::|||.::|||..||.:|||:|.:|:.|::...|:..|:|..:..|::|:|||::
Frog   819 VCFTLSEKVPLFGLEAIWRNGIAVGHVRRADYGFTINKTIAYGYIRNPEGGAVSPDFVRSGEYKL 883

  Fly   859 DILGKKYRADCHLRSPFDPTGQRVLGNY 886
            :.:|..|.|:.||:|||||...||.|.|
Frog   884 ERMGIAYPAEAHLKSPFDPNNMRVKGFY 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	205/381 (54%)
		NADB_Rossmann	37..>76	CDD:304358	28/39 (72%)
		nuc_hydro	203..>281	CDD:294156	30/78 (38%)
		FAO_M	398..449	CDD:292961	29/50 (58%)
		GcvT	446..884	CDD:223481	208/439 (47%)
		GCV_T	456..767	CDD:279857	147/311 (47%)
		GCV_T_C	774..867	CDD:285832	40/92 (43%)
sardh	XP_031747425.1	NADB_Rossmann	<5..>100	CDD:419666	33/57 (58%)
		DadA	56..440	CDD:223737	207/383 (54%)
		FAO_M	423..478	CDD:406692	30/54 (56%)
		GcvT	472..909	CDD:223481	208/439 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I719
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H5149
Inparanoid	1	1.050	896	1.000	Inparanoid score	I381
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D813396at2759
OrthoFinder	1	1.000	-	-		FOG0008062
OrthoInspector	1	1.000	-	-		oto103750
Panther	1	1.100	-	-	LDO	PTHR13847
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3396
SonicParanoid	1	1.000	-	-		X6012
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.190