DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sardh and dmgdh

DIOPT Version :9

Sequence 1:	NP_611263.1	Gene:	Sardh / 37026	FlyBaseID:	FBgn0034276	Length:	894	Species:	Drosophila melanogaster
Sequence 2:	XP_021324608.1	Gene:	dmgdh / 100141496	ZFINID:	ZDB-GENE-080227-8	Length:	862	Species:	Danio rerio

Alignment Length:	883	Identity:	274/883 - (31%)
Similarity:	422/883 - (47%)	Gaps:	77/883 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WRHRILQQASRRGISKQVREDGG--ARREPSGFLPGAADVVVIGGGSAGCHTLYHLARRGVK-AV 63
            ||.|:.::.:|...:.......|  |||     |..:||.:|||||..|....||||:.|.| .|
Zfish    16 WRRRVPRERARSFATDPREASAGVLARR-----LQDSADTLVIGGGCVGVSVAYHLAKAGQKDVV 75

  Fly    64 LLERAQLTAGTTWHTAGLLWRLRPNDVDIQLLANSRRMLQQLEEETELDPGWIQNGGIFIAHNET 128
            |||:::||||:|||.|||.....|.....::...|.::.:|||.||....|:.|.|.|.:|....
Zfish    76 LLEKSELTAGSTWHAAGLTTYYHPGINLKKIHYYSIKLFEQLEAETGQAVGFHQPGSIRLASTPV 140

  Fly   129 RLDEYRRLATVGSALGIENQVLSPEDTQKLFPLLDPSAFVGALYSPGDGVMDPAMLCAALKKAAT 193
            |:||.:...:..........::.||..|:|||||:....:..||:||||.:||..|..||...|.
Zfish   141 RVDELKYQMSRTRWHPTPQFLIEPERIQQLFPLLNMDKVLAGLYNPGDGHIDPYSLTMALAAGAR 205

  Fly   194 NLGAQVIENCGVDDLLLEQTARGKKVVGVSTPFGDIKAEKVVNATGVWGRDLVARHGTHLPLVPM 258
            ..|||:.....|..|...:..|.    .|.||.|.|:|.::|||||.|.|:|....|...|.||:
Zfish   206 MYGAQIYCPAAVTGLTPTEDGRW----DVQTPHGTIRANRIVNATGFWARELGQMLGFPHPTVPV 266

  Fly   259 KHAYIVSESIPGVRG----LPNIRDHDYSTYFRIQGDAICMGGYE-------PNPILLEPVPKDF 312
            .|.|:|:.|:|.|:.    ||.|||.:.|.|.|.:.|.:..|.||       .:..:.:.||..|
Zfish   267 HHQYVVTGSVPEVQALQTELPVIRDLEGSYYLRQERDGLLFGPYEREEKMKLQDSWITDGVPAGF 331

  Fly   313 HFGLYELDWSVFETHVEGAQKLCPSYAKYGVKSTVCGPESFTPDHKPLMGPDPNLDGLYHNCGFN 377
            ...|:|.|......|||.|.::.|......:.:.|.||.::|||..|::||.......:...||
Zfish   332 GKELFESDLDRIMDHVEMAMEMVPVLKNADIINIVSGPITYTPDLLPMIGPHQGARNYWTAIGF- 395

  Fly   378 SAGMMFGGGCGEQTALWVIQGQPDLPMFGFDLRRFTQEQGKAIQWIREKSHESYVKNYSMVFKYD 442
            ..|::..||.|...:.|:|.|:|...:...|..|:  .....:.::..|:.|||..|..:.|..:
Zfish   396 GYGIIHSGGVGRFLSDWIINGEPPYDLIECDPNRY--GHWTTVPYVCAKARESYGFNNVVGFPKE 458

  Fly   443 QPLAGRDFQKDPLHDEMMKAGAVMEEKQGWERPGFFLPTGSKKAVVQPYDWYGSYVHQRHKDSEY 507
            :..|||...:.....|::|....|....|||:|.:|...|.               |..::.|
Zfish   459 ERFAGRPTVRVSGVYELLKHRCSMGFHSGWEQPHYFHKPGD---------------HTGYRPS-- 506

  Fly   508 ERVLDGDLHYSRFSEYHDLIGSEALACRNNAVVFNMSYFAKLLLDGPQAQEAADWLFSANTNRDP 572
                      .|.:.:...:|.|.........|.::|.|.|:.:.|..::...|.|. |||....
Zfish   507 ----------FRRTNWFAPVGRECAQVMQAVGVIDLSPFGKMKVTGADSERLLDRLL-ANTLPKV 560

  Fly   573 SKTVYTCALNDAGGVEADVTISRLAPGSGEVYNPKINGQGFYIVAGGASAFYTYSVLLAEIRRKG 637
            .:|..:..|...|.|.|::|::...||.            |.::.|..|..:....:..|....|
Zfish   561 GQTNISHMLTPRGRVYAELTVTHTQPGE------------FLLITGSGSELHDLRWIEREAADGG 613

  Fly   638 FNASLKDLTAELGVISIQGPNSRKILQPLIDCDLSDEHVAPNSTRLAKFGDVGLRLLRVSFVGEL 702
            ::..:.::|.|:||:.|.||.||.:||.|...|||:........|..:.....::.:|:|:.|||
Zfish   614 YDVCVTNVTDEIGVLGIAGPKSRTVLQKLTSADLSESSFRFLQCRTIELAGATVQAIRISYTGEL 678

  Fly   703 GYELHVPKKDCAAVYRSLMKAGAGEDLRNAGYRSLYSLSSEKGYHLWSFDLRPDDTPLEAGLGFT 767
            |:||::..::.:|||::||:||..|::.:.|..::.||..|||:..|..::..|..||||||.:.
Zfish   679 GWELYMDMRNMSAVYQALMEAGRDENIDDFGTYAMNSLRLEKGFRAWGAEMNCDTNPLEAGLDYF 743

  Fly   768 CR-KTGADYRGKAAIENQRAEGLKKRLVYLTLR-DQVPIWGLEGVYRNGEPVGILRRAEYAYTLG 830
            .: ...||:.||.|:...:|:||.:||.:|||. |.:...|.|.|:.|||.||......|:|:..
Zfish   744 IKLNKPADFIGKQALLEIKAQGLSRRLAFLTLNTDDIDPEGNESVWHNGEVVGNTTSGSYSYSTH 808

  Fly   831 KSLGQTYVSRPDGKIIDADYIRNGE-YEVDILGKKYRA 867
            :|:...|:  |.|      ..:.|: .||::||:||.|
Zfish   809 QSVAFAYL--PVG------LTQLGQKVEVELLGQKYSA 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sardh	NP_611263.1	DadA	33..412	CDD:223737	137/390 (35%)
		NADB_Rossmann	37..>76	CDD:304358	22/39 (56%)
		nuc_hydro	203..>281	CDD:294156	32/81 (40%)
		FAO_M	398..449	CDD:292961	12/50 (24%)
		GcvT	446..884	CDD:223481	122/425 (29%)
		GCV_T	456..767	CDD:279857	83/310 (27%)
		GCV_T_C	774..867	CDD:285832	34/94 (36%)
dmgdh	XP_021324608.1	DadA	44..433	CDD:223737	138/395 (35%)
		FAO_M	419..466	CDD:318549	11/48 (23%)
		GcvT	466..855	CDD:223481	119/421 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53337
OrthoDB	1	1.010	-	-		D96522at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3396
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.960