DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5002 and slc26a4.3

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001107135.1	Gene:	slc26a4.3 / 779605	XenbaseID:	XB-GENE-950380	Length:	778	Species:	Xenopus tropicalis

Alignment Length:	557	Identity:	143/557 - (25%)
Similarity:	257/557 - (46%)	Gaps:	85/557 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EDNLYREQLPNVSTLIRDGGRKLCRPSTVTNK---------FPILKWLPRYR-LEYIMQDFIAGF 59
            :||   |:...|...::|..:|.|   :.|:|         ||:|.|||:|| .|:.:.|.|:|.
Frog    30 DDN---ERKERVQKTVQDRIKKNC---SCTSKKAYFIVKKFFPVLDWLPKYRWKEWFVNDLISGV 88

  Fly    60 TVGLTTIPQAIAYGVVAGLEPQYGLYSAFMGCFTYIVFGSCKDVTIATTAIMALMVNQYA-TISP 123
            :.||....|.:|:.::|.:...|||||:|....||...|:.|.:::....:::|||.... :|:|
Frog    89 STGLVGTLQGLAFALLAAVPVGYGLYSSFFPILTYFFLGTSKHISVGPFPVVSLMVGSVVLSIAP 153

  Fly   124 D--YAVL--------------------------VCFLAGCIVLLLGLLNMGVLVRFISIPVITGF 160
            |  :|:|                          :.||.|.|.|.||:..:|.:||:::.|::.||
Frog   154 DEKFAILGNATGLNKTIIDTVARDAARIAVSGTLSFLIGIIQLALGIFQIGFIVRYLADPLVGGF 218

  Fly   161 TMAAATTIGSAQINNIVGL-TSPSNDLLP---AWKNFFTHLTSIRLWDALLGVSSLVFLLLMTRV 221
            |.|||..:..:|...::.: |...|.:|.   ..::.|.::....:.|.:.|:.:.|..:::..:
Frog   219 TTAAAFQVFVSQFKLVLNVPTQNYNGVLSIIYTIRDIFMNIRLTNIADLIAGLLTFVVCVVVKEI 283

  Fly   222 KDIKWGNRIFWKYLGLSRNALAV-IFGTFLAYILSRDGNQPFRVTGNITAGVPPFRLPPFSTTVD 285
            .|         :|..:.|..:.: :..|.:|..:|...|...:....|.|.:|...:||.:..|
Frog   284 ND---------RYKRIFRVPIPIEVIVTIVATGISYGVNLHAKYNAGIVATIPSGFIPPMTPDV- 338

  Fly   286 GEYVSFGEMISTVGASLGSIPLISILEIVAISKAFSKGKI--------VDASQEMVALGMCNIMG 342
                   .:.|.:|:|..||      .|||.:.|.|.||:        ||.:||.:|.|:.|:.|
Frog   339 -------SLFSQIGSSAFSI------GIVAYAVAVSVGKVYATKHNYEVDGNQEFIAFGISNLFG 390

  Fly   343 SFVLSMPVTGSFTRTAVNNASGVKTPLGGAVTGALVLMALAFLTQTFYFIPKCTLAAIIIAAMIS 407
            ........|.:.:||||..::|.:|.:.|.::..:||:|:..|.:....:.|..||||:||.:..
Frog   391 GAFSCFCATTALSRTAVQESTGGRTQIAGIISAGIVLIAIVALGRLLEPLQKSVLAAIVIANLKG 455

  Fly   408 LV-ELHKIKDMWKSKKKDLFPFVVTVLTCMFWSLEYGILCGIGANMVYILYSSARPHVDIKLEKI 471
            :. ::..|..:||..|.|...:|.|.:..:|..|:.|:|.|:...:..||.....|... .|..:
Frog   456 MFWQVFDIPRLWKQNKWDSAIWVFTCIASIFLGLDSGLLAGLLFGLATILLRVQFPSCG-ALGNV 519

  Fly   472 NGHEV--SVVDVKQKLDYASAEYLKEKVVRFLNNQNG 506
            .|.::  :|.:.|..::....:.::.....|..|.:|
Frog   520 PGTDIYKNVKEYKNLIEPEGVKIIRHTSGMFYGNIDG 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	135/526 (26%)
		HCO3_cotransp	103..>385	CDD:304903	77/323 (24%)
		STAS	469..>544	CDD:294402	6/40 (15%)
slc26a4.3	NP_001107135.1	sulP	66..723	CDD:273284	133/515 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040