DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5002 and Slc26a11

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_006533481.1	Gene:	Slc26a11 / 268512	MGIID:	2444589	Length:	610	Species:	Mus musculus

Alignment Length:	569	Identity:	231/569 - (40%)
Similarity:	347/569 - (60%)	Gaps:	39/569 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 CRPSTVTNKFPILKWLPRYRLEYIMQDFIAGFTVGLTTIPQAIAYGVVAGLEPQYGLYSAFMGCF 92
            |..:.:..:.|:|.|:|.|.|:::..|||||.:||||.||||:||..||||.|||||||||||||
Mouse    25 CSATALRRRLPVLAWVPDYSLQWLRLDFIAGLSVGLTVIPQALAYAEVAGLPPQYGLYSAFMGCF 89

  Fly    93 TYIVFGSCKDVTIATTAIMALMVNQYATISPDYAVLVCFLAGCIVLLLGLLNMGVLVRFISIPVI 157
            .|...|:.:|||:..||||:|:|:.|....|.||||:.||:|||.|.:|||::|.|:.|||.|||
Mouse    90 VYFFLGTSRDVTLGPTAIMSLLVSFYTFREPAYAVLLAFLSGCIQLAMGLLHLGFLLDFISCPVI 154

  Fly   158 TGFTMAAATTIGSAQINNIVGLTS-PSNDLLPAWKNFFTHLTSIRLWDALLGVSSLVFLLLMTRV 221
            .|||.||:.|||..||.|::||.. |....|..:..|. |:...|:.||:||::|::.||::..:
Mouse   155 KGFTSAASITIGFGQIKNLLGLQKIPRQFFLQVYHTFL-HIGETRVGDAVLGLASMLLLLVLKCM 218

  Fly   222 KD------------IKWGNRIFWKYLGLSRNALAVIFGTFLAYILSRDGNQPFRVTGNITAGVPP 274
            ::            :|:...:.|. :..:||||.|.....:||.....|:.||.:||.|..|:||
Mouse   219 REHMPPPHPEMPLAVKFSRGLVWT-VTTARNALVVSSAALIAYAFEVTGSHPFVLTGKIAEGLPP 282

  Fly   275 FRLPPFSTTVDGEYVSFGEMISTVGASLGSIPLISILEIVAISKAFS--KGKIVDASQEMVALGM 337
            .|:||||.|.|.:.:||.||:..:||.|..:||:.:||.:|::|:|:  ....:||:||::|:|:
Mouse   283 VRIPPFSVTRDNKTISFSEMVQDMGAGLAVVPLMGLLESIAVAKSFASQNNYRIDANQELLAIGL 347

  Fly   338 CNIMGSFVLSMPVTGSFTRTAVNNASGVKTPLGGAVTGALVLMALAFLTQTFYFIPKCTLAAIII 402
            .|::||.|.|.||||||.|||||..:||.||.||.|||||||::|.:||..|.:|||..|||:||
Mouse   348 TNVLGSLVSSYPVTGSFGRTAVNAQTGVCTPAGGLVTGALVLLSLNYLTSLFSYIPKSALAAVII 412

  Fly   403 AAMISLVELHKIKDMWKSKKKDLFPFVVTVLTCMFWSLEYGILCGIGANMVYILYSSARPHVDIK 467
            .|:..|.::...:.:|:.::.||.|..||.| ..||.::||||.|...:::.:|:|.|||..
Mouse   413 TAVTPLFDVKIFRSLWRVQRLDLLPLCVTFL-LSFWEIQYGILAGSLVSLLILLHSVARPKT--- 473

  Fly   468 LEKINGHEVSVVDVKQKLDYASAEYLKEKVV-RFLNNQNGETQLVVIKGEEINSIDYTVAMNIVS 531
              :::..::.|:.....|.:.:.:.|:|.:. |.|  :....:..|::...|:|:||||.:.:..
Mouse   474 --QVSEGQIFVLQPASGLYFPAIDALREAITNRAL--EASPPRSAVLECTHISSVDYTVIVGLGE 534

  Fly   532 MKGDLEALNCAMICWNWNIASAGV---VCR--LNNDLRPIFKFDLSLEE 575
            :..|.:....|       :|..|:   |.|  |..||:. |::..:|||
Mouse   535 LLEDFQKKGVA-------LAFVGLQVPVLRTLLAADLKG-FRYFTTLEE 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	225/548 (41%)
		HCO3_cotransp	103..>385	CDD:304903	131/296 (44%)
		STAS	469..>544	CDD:294402	15/75 (20%)
Slc26a11	XP_006533481.1	sulP	35..559	CDD:273284	223/540 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831456
Domainoid	1	1.000	355	1.000	Domainoid score	I982
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1841
Isobase	1	0.950	-	0	Normalized mean entropy	S2728
OMA	1	1.010	-	-		QHG55446
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	1	1.000	-	-		otm43049
orthoMCL	1	0.900	-	-		OOG6_100144
Panther	1	1.100	-	-	LDO	PTHR11814
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1414
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.740