DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5002 and Slc26a8

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	XP_011244686.1	Gene:	Slc26a8 / 224661	MGIID:	2385046	Length:	1027	Species:	Mus musculus

Alignment Length:	569	Identity:	125/569 - (21%)
Similarity:	240/569 - (42%)	Gaps:	94/569 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FPILKWLPRYRL-EYIMQDFIAGFTVGLTTIPQAIAYGVVAG--LEPQYGLYSAFMGCFTYIVFG 98
            ||.|:|:..||. ::::.|.:||.:|||..:||.:...::..  :.|....|:||.....|::||
Mouse   103 FPFLEWICLYRFKDWLLGDLLAGLSVGLVQVPQGLILSLLTRQLIPPLNVTYAAFCSSVIYVIFG 167

  Fly    99 SCKDVTIAT-TAIMALMVNQY-------------ATISPDYAV---------------LVCFLAG 134
            ||..::|.. ..:.|||:|..             ..:..|::|               ...||.|
Mouse   168 SCHQMSIGPFFLVSALMINVLKDRPFNNGHLILGTFVKDDFSVPTFYLSYNRSLSMVASTTFLTG 232

  Fly   135 CIVLLLGLLNMGVLVRFISIPVITGFTMAAATTIGSAQINNIVGL-----TSPSNDLLPAWKNFF 194
            .|.|.:|:|.||.:..::.....:.:..|.|..|..||:..|:|:     ..|.        :|.
Mouse   233 IIQLSMGMLGMGFMATYLPEAATSAYLAAVALHIILAQMTCILGIMVSFHAGPI--------SFI 289

  Fly   195 THLTSIRLWDALLGVSSLVFLLLMTRVKDIKWGNRIFWKYLGLSRNALAVIFGTFLAYILSRDGN 259
            .::  |....||...:|...||.:|.|..::..     |.:.::.|...:.|...|..||...
Mouse   290 YNI--INYCIALPKANSTSILLFITSVVALRIN-----KCIRITFNRYPIEFPMELLLILGFS-- 345

  Fly   260 QPFRVTGNITAGVPP----FRLPPFSTTVDGEYVSFGEMISTVGASLGSIPLISILEIVAISKAF 320
               .:|..||.....    ..:.|:| .|..|...|| ::|.|.....|:..:|...::::.|..
Mouse   346 ---LLTSKITMATENSKMLMNMIPYS-FVFPENPEFG-ILSRVVLQALSLSFVSSFLLISLGKKI 405

  Fly   321 SK--GKIVDASQEMVALGMCNIMGSFVLSMPVTGSFTRTAVNNASGVKTPLGGAVTGALVLMALA 383
            :.  ....:::|:::|:|:||::.||......|||.:||.:.:.||.:......|...::|:.:.
Mouse   406 ANFHNYRTNSNQDLIAIGLCNLLSSFFKCCVFTGSLSRTTIQDKSGGRQQFASLVGAGVMLLLMV 470

  Fly   384 FLTQTFYFIPKCTLAAIIIAAMISLVE-LHKIKDMWKSKKKDLFPFVVTVLTCMFWSLEYGILCG 447
            .:...|:.:|...||.||::.::..:| ::.:..:|:..:.:...::||..:.:...|:.|:|..
Mouse   471 KMESFFHNLPNAVLAGIILSNVVPYLEAIYNLPSLWRQDQYECIIWMVTFSSAILLGLDVGLLIS 535

  Fly   448 IGANMVYILYSSAR---------PHVDIKLEKINGHE-------VSVVDVKQKLDYASAEYLKEK 496
            :......|...|.|         |:.:| ...:|.:.       |.:......:.:.:..:||:|
Mouse   536 LAFTFFVITIRSHRTKILVLGQIPNTNI-YRNVNDYREVILIPGVKIFQCCSSITFVNVYHLKQK 599

  Fly   497 VVRFLNNQNGETQLVVIKGEEINSIDYTVAMNIVSMKGDLEALNCAMIC 545
            |::.:|...     :.:|.|||.::.:....:|...|      .|...|
Mouse   600 VLKEVNMVK-----LPLKEEEIYTLFHESETSIAENK------LCRCFC 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	125/569 (22%)
		HCO3_cotransp	103..>385	CDD:304903	69/321 (21%)
		STAS	469..>544	CDD:294402	14/81 (17%)
Slc26a8	XP_011244686.1	sulP	104..610	CDD:273284	116/533 (22%)
Slc26a8	XP_011244686.1	STAS_SulP_like_sulfate_transporter	<747..806	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820