DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5002 and Slc26a2

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_031911.1	Gene:	Slc26a2 / 13521	MGIID:	892977	Length:	739	Species:	Mus musculus

Alignment Length:	669	Identity:	158/669 - (23%)
Similarity:	288/669 - (43%)	Gaps:	136/669 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 IRDGGRKLCRPSTVTNKFPILKWLPRYRL-EYIMQDFIAGFTVGLTTIPQAIAYGVVAGLEPQYG 83
            :|||         ..:.||:|:|||:|.| :.|:.|.::|..||:..:||:|||.::||.||.||
Mouse    85 VRDG---------AFDFFPVLRWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPIYG 140

  Fly    84 LYSAFMGCFTYIVFGSCKDVTIATTAIMALMVNQYA-----TISPD------------------- 124
            ||::|.....|.:||:.:.:::....|:.||:.:..     ...||
Mouse   141 LYTSFFASIIYFLFGTSRHISVGIFGILCLMIGEVVDRELHKACPDTDATSSSIAVFSSGCVVVN 205

  Fly   125 -----------YAV----LVCFLAGCIVLLLGLLNMGVLVRFISIPVITGFTMAAATTIGSAQIN 174
                       ||:    .|.|:||...:.:|...:|.:..::|..:::||...|:.||.::|..
Mouse   206 HTLDGLCDKSCYAIKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAK 270

  Fly   175 NIVGLTSPSN----DLLPAWKNFFTHLTSIRLWDALLGVSSLVFLLLMTRVKDIKWGNRIFWKYL 235
            .::||:.|.:    .::..|.:.|.::.:..:.|.   ::||:.||::...|::   |..|...|
Mouse   271 YLLGLSLPRSHGVGSVITTWIHIFRNIRNTNICDL---ITSLLCLLVLVPSKEL---NEHFKDKL 329

  Fly   236 --GLSRNALAVIFGTFLAYILSRDGNQPFRVTGNITAGVPPFRLPPFSTTVDGEYVSFGEMISTV 298
              .:....:.|:..|..::....:||....:.|:|..|..|.:.|.:|            :|..|
Mouse   330 KAPIPVELIVVVAATLASHFGKLNGNYNSSIAGHIPTGFMPPKAPDWS------------LIPNV 382

  Fly   299 GASLGSIPLISILEIVAISKAFSK--GKIVDASQEMVALGMCNIMGSFVLSMPVTGSFTRTAVNN 361
            .....:|.:|.....|::|:.|:|  |..|.|:|||.|:|.|||:.||...:..:.:..:|.|..
Mouse   383 AVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCITTSAALAKTLVKE 447

  Fly   362 ASGVKTPLGGAVTGALVLMALAFLTQTFYFIPKCTLAAIIIAAMI-SLVELHKIKDMWKSKKKDL 425
            ::|.:|.|...||..::|:.|..:...||.:.||.|..|.|..:. :|::...:..||:..:.|.
Mouse   448 STGCQTQLSAIVTALVLLLVLLVIAPLFYSLQKCVLGVITIVNLRGALLKFRDLPKMWRLSRMDT 512

  Fly   426 FPFVVTVLTCMFWSLEYGILCGIGANMVYILYSSARPHVDI--------KLEKINGHE------- 475
            ..:.||:|:....|.|.|:|.|:..:|..::..:.:|...:        ..|.|:.::
Mouse   513 VIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQKPKNSLLGLEEESETFESISTYKNLRSKSG 577

  Fly   476 --------------------------VSVVDVKQKLDYASAEYLKEKVVRF----------LNNQ 504
                                      ::.|.||.....|:...|||::|.|          |::.
Mouse   578 IKVFRFIAPLYYINKECFKSALYKKALNPVLVKAAWKKAAKRKLKEEMVTFRGDPDEVSMQLSHD 642

  Fly   505 NGETQLVVIKGEEINSIDYTVAMNIVSMKGDLEALNCAMICWNWNIA-----SAGVVCRLNNDLR 564
            ..|...:||....|..:|......:..::.|.||:...::....|.:     :.|..|:...:..
Mouse   643 PLEVHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAVGIQVLLAQCNPSVRDSLARGEYCKKEEETL 707

  Fly   565 PIFKFDLSLEEVVAGHFDS 583
            ..:    ||.|.||...||
Mouse   708 LFY----SLSEAVAFAEDS 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	148/632 (23%)
		HCO3_cotransp	103..>385	CDD:304903	74/328 (23%)
		STAS	469..>544	CDD:294402	20/117 (17%)
Slc26a2	NP_031911.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47
		sulP	94..715	CDD:273284	149/642 (23%)
		STAS	570..707	CDD:294402	21/136 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820