DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5002 and Slc26a2

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_476468.1	Gene:	Slc26a2 / 117267	RGDID:	620622	Length:	739	Species:	Rattus norvegicus

Alignment Length:	685	Identity:	161/685 - (23%)
Similarity:	293/685 - (42%)	Gaps:	139/685 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LYREQLPNVSTLIRDGGRKL-----CRPSTVTNK----FPILKWLPRYRL-EYIMQDFIAGFTVG 62
            |:.:...|:..|:.   |||     |..:.:.|:    ||:|:|||:|.| :.|:.|.::|..||
  Rat    58 LHEKPDTNIRQLVM---RKLQKSCQCNATKIRNRIFDFFPVLRWLPKYDLKKNILGDMMSGLIVG 119

  Fly    63 LTTIPQAIAYGVVAGLEPQYGLYSAFMGCFTYIVFGSCKDVTIATTAIMALMVNQYA-----TIS 122
            :..:||:|||.::||.||.||||::|.....|.:||:.:.:::....|:.||:.:..     ...
  Rat   120 ILLVPQSIAYSLLAGQEPIYGLYTSFFASIIYFLFGTSRHISVGIFGILCLMIGEVVDRELHKAC 184

  Fly   123 PD------------------------------YAV----LVCFLAGCIVLLLGLLNMGVLVRFIS 153
            ||                              ||:    .|.|:||...:.:|...:|.:..::|
  Rat   185 PDIDTTSSSIAMFSNGCVVVNHTLDGLCDKSCYAIKIGSTVTFMAGVYQVAMGFFQVGFVSVYLS 249

  Fly   154 IPVITGFTMAAATTIGSAQINNIVGLTSPSND----LLPAWKNFFTHLTSIRLWDALLGVSSLVF 214
            ..:::||...|:.||.::|...::||:.|.::    ::..|.:.|.::....:.|.   ::||:.
  Rat   250 DALLSGFVTGASFTILTSQAKYLLGLSLPRSNGVGSVITTWIHIFRNIHKTNICDL---ITSLLC 311

  Fly   215 LLLMTRVKDIKWGNRIFWKYL--GLSRNALAVIFGTFLAYILSRDGNQPFRVTGNITAGVPPFRL 277
            ||::...|::   |..|...|  .:....:.|:..|..::....:.|....:.|.|..|..|.:.
  Rat   312 LLVLVPTKEL---NEYFKSKLPAPIPTELIVVVAATLASHFGKLNENYNSSIAGQIPTGFMPPQA 373

  Fly   278 PPFSTTVDGEYVSFGEMISTVGASLGSIPLISILEIVAISKAFSK--GKIVDASQEMVALGMCNI 340
            |.:|            :|..|.....:|.:|.....|::|:.|:|  |..|.|:|||.|:|.|||
  Rat   374 PDWS------------LIPNVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNI 426

  Fly   341 MGSFVLSMPVTGSFTRTAVNNASGVKTPLGGAVTGALVLMALAFLTQTFYFIPKCTLAAIIIAAM 405
            :.||...:..:.:..:|.|..::|.:|.|...||..::|:.|..:...||.:.||.|..|.|..:
  Rat   427 IPSFFHCITTSAALAKTLVKESTGCQTQLSAIVTSLVLLLVLLLIAPLFYSLQKCVLGVITIVNL 491

  Fly   406 I-SLVELHKIKDMWKSKKKDLFPFVVTVLTCMFWSLEYGILCGIGANMVYILYSSARPHVDIK-- 467
            . :|::...:..||:..:.|...:.||:|:....|.|.|:|.|:..:|..::..:..|.:.:.
  Rat   492 RGALLKFRDLPKMWRLSRMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQMPKISLLGL 556

  Fly   468 ------LEKINGHE---------------------------------VSVVDVKQKLDYASAEYL 493
                  .|.|:.::                                 ::.|.||.....|:...|
  Rat   557 EEESEIFESISTYKNLRSKSGIKVFRFIAPLYYINKECFKSALYKKTLNPVLVKAAWKKAAKRKL 621

  Fly   494 KEKVVRF----------LNNQNGETQLVVIKGEEINSIDYTVAMNIVSMKGDLEALNCAMICWNW 548
            ||:.|.|          |::...|...|||....|..:|......:..::.|.||:...::....
  Rat   622 KEETVTFHGDPDEVSMQLSHDPLELHTVVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQC 686

  Fly   549 NIA-----SAGVVCRLNNDLRPIFKFDLSLEEVVA 578
            |.:     :.|..|:...:....:    ||.|.||
  Rat   687 NPSVRDSLAKGEYCKKEEENLLFY----SLSEAVA 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	148/636 (23%)
		HCO3_cotransp	103..>385	CDD:304903	73/328 (22%)
		STAS	469..>544	CDD:294402	21/117 (18%)
Slc26a2	NP_476468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44
		sulP	94..715	CDD:273284	149/642 (23%)
		STAS	570..707	CDD:294402	22/136 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820