DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5002 and SLC26A9

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_599152.2	Gene:	SLC26A9 / 115019	HGNCID:	14469	Length:	887	Species:	Homo sapiens

Alignment Length:	530	Identity:	124/530 - (23%)
Similarity:	229/530 - (43%)	Gaps:	90/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 STVTNKFPILKWLPRYRL-EYIMQDFIAGFTVGLTTIPQAIAYGVVAGLEPQYGLYSAFMGCFTY 94
            :.|....|:|.|||:|:: :||:.|.:.|.:.|...:||.:|:.::|.|....||||:|....||
Human    50 AVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTY 114

  Fly    95 IVFGSCKDVTIATTAIMALMV-NQYATISPD---------------------------YAVLVCF 131
            ...|....:...|.|:::::| |....::|:                           .|.|.|
Human   115 FFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLAC- 178

  Fly   132 LAGCIVLLLGLLNMGVLVRFISIPVITGFTMAAATTIGSAQINNIVGLTSPSNDLLPAWKNFFTH 196
            |...|.:.||.:..|.:..::|...|.||..||...|..:.:..|.|||.||          :|.
Human   179 LTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPS----------YTG 233

  Fly   197 -----LTSIRLWDAL--LGVSSLVFLLL----MTRVKDI--KWGNRIFWKYLGLSRNALAVIFGT 248
                 .|.|.:...|  ..::||:|.|:    :..||::  ::.::|.:.   :....:.|:..|
Human   234 PGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFP---IPTEMIVVVVAT 295

  Fly   249 FLAYILSRDGNQPFRVTGNITAGVPPFRLPPFSTTVDGEYVSFGEMISTVGASLGSIPLISILEI 313
            .::...........::.|.|..|.|    .|.|..|.    .:.:||.|.    .|:.::|.:..
Human   296 AISGGCKMPKKYHMQIVGEIQRGFP----TPVSPVVS----QWKDMIGTA----FSLAIVSYVIN 348

  Fly   314 VAISKAFSK--GKIVDASQEMVALGMCNIMGSFVLSMPVTGSFTRTAVNNASGVKTPLGGAVTGA 376
            :|:.:..:.  |..||::|||:|||..|..|||.....:..:.:.|...:.:|.|:.:.......
Human   349 LAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSL 413

  Fly   377 LVLMALAFLTQTFYFIPKCTLAAII-IAAMISLVELHKIKDMWKSKKKDLFPFVVTVLTCMFWSL 440
            :|::.:..|....|.:||..|.|:| :....||.:|.....:|:..|.|...:||:.|:..|.||
Human   414 VVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSL 478

  Fly   441 EYGILCGIGANMVYILYSS-----------------ARPHVDIKLEKINGHEVSVVDVKQKLDYA 488
            .||:..|:..:::.:::.:                 ..|....:.:.|.|  :.::.....|.:|
Human   479 PYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQG--IKIITYCSPLYFA 541

  Fly   489 SAEYLKEKVV 498
            ::|..::||:
Human   542 NSEIFRQKVI 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	123/525 (23%)
		HCO3_cotransp	103..>385	CDD:304903	69/324 (21%)
		STAS	469..>544	CDD:294402	7/30 (23%)
SLC26A9	NP_599152.2	Sulfate_transp	74..468	CDD:279284	98/419 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..650
		STAS_SulP_like_sulfate_transporter	<662..730	CDD:132913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820