DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5002 and Slc26a3

DIOPT Version :9

Sequence 1:	NP_611262.1	Gene:	CG5002 / 37025	FlyBaseID:	FBgn0034275	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_446207.1	Gene:	Slc26a3 / 114629	RGDID:	620623	Length:	757	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	130/551 - (23%)
Similarity:	247/551 - (44%)	Gaps:	125/551 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FPILKWLPRYRL-EYIMQDFIAGFTVGLTTIPQAIAYGVVAGLEPQYGLYSAFMGCFTYIVFGSC 100
            |||..|||.|:: |:::.|.::|.:.||..:.|.:|:.::..:.|.||||:||....||...|:.
  Rat    58 FPIASWLPAYKIKEWLLSDIVSGISTGLVAVLQGLAFALLVNIPPAYGLYAAFFPVITYFFLGTS 122

  Fly   101 KDVTIATTAIMALMVNQYAT-------ISPD-----------------YAVLVCFLAGCIVLLLG 141
            :.:::....::::||....|       .||.                 .|..|..|:|.|.||||
  Rat   123 RHISVGPFPVLSMMVGVVVTRVASGSDTSPALSSSSAENDSMIEEKVMVAASVTVLSGIIQLLLG 187

  Fly   142 LLNMGVLVRFISIPVITGFTMAAATTIGSAQINNIVGLTSPSN----DLLPAWKNFFTHLTSIRL 202
            :|.:|.:|.::|..:|:|||.|||..:..:|:..::.||.|::    .:....::.|:.:....:
  Rat   188 VLQIGFVVIYLSESLISGFTTAAAIHVLVSQLKFMLQLTVPAHSDPFSIFKVLESVFSQIQKTNI 252

  Fly   203 WDALLGVSSLVFLLLMTRVKDIKWGNRIFWKYLGLSRNALAV---------IFGTFLAYILSRDG 258
            .|.   |:|::.|:::..||:|.      .:|    |:.|.|         :..|.::|..:.:.
  Rat   253 ADL---VTSVIILVVVFVVKEIN------QRY----RSKLPVPIPIELIMTVIATGISYGCNFEQ 304

  Fly   259 NQPFRVTGNITAGVPPFRLPPFSTTVDGEYVSFGEMISTVGASLGSIPLISILEIVAISKAFSKG 323
            .....|.||::.|..    ||.:.:|:       ....|:|...|       :.||..:.|||..
  Rat   305 RFGVAVVGNMSLGFQ----PPITPSVE-------VFQDTIGDCFG-------IAIVGFAVAFSVA 351

  Fly   324 KI--------VDASQEMVALGMCNIMGSFVLSMPVTGSF---------TRTAVNNASGVKTPLGG 371
            .:        :|.:||::|||:.||.         ||:|         :|:.|..::|.||.:.|
  Rat   352 SVYSLKYDYPIDGNQELIALGVSNIF---------TGAFKGFAGSTALSRSGVQESTGGKTQVAG 407

  Fly   372 ---AVTGALVLMALAFLTQTFYFIPKCTLAAIIIAAMIS-LVELHKIKDMWKSKKKDLFPFVVTV 432
               ||...:|::|:.||.|.   :.|..|||:.:..:.. |::..:|..:||..|.|...:::|.
  Rat   408 LLSAVIVLIVIVAIGFLLQP---LQKSVLAALALGNLKGMLMQFAEIGRLWKKDKYDCLIWIMTF 469

  Fly   433 LTCMFWSLEYGILCGIGANMVYILYSSARPH----VDIKLEKINGHEVSVVDVKQ---------- 483
            :..:...|..|:...:...::.|::.:..|.    .::....|..::.:..||.:
  Rat   470 IFAIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANVGRSNIYKNKKNYADVYEPEGVKIFRCP 534

  Fly   484 -KLDYASAEYLKEKVV--------RFLNNQN 505
             .:.:|:..:.|:|::        |.|..:|
  Rat   535 SPIYFANIGFFKQKLIDAVGFNPLRILRKRN 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5002	NP_611262.1	SUL1	36..564	CDD:223732	130/551 (24%)
		HCO3_cotransp	103..>385	CDD:304903	79/338 (23%)
		STAS	469..>544	CDD:294402	9/56 (16%)
Slc26a3	NP_446207.1	Sulfate_transp	73..468	CDD:395733	108/437 (25%)
Slc26a3	NP_446207.1	STAS_SulP_like_sulfate_transporter	519..705	CDD:132913	8/47 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0659
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D252952at33208
OrthoFinder	1	1.000	-	-		FOG0000041
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X49
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820