DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and RPN14

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_011511.3	Gene:	RPN14 / 852880	SGDID:	S000002972	Length:	417	Species:	Saccharomyces cerevisiae

Alignment Length:	328	Identity:	69/328 - (21%)
Similarity:	129/328 - (39%)	Gaps:	96/328 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AFDSFKMPM--------------LPSQFHLENSMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVS 73
            |.|:.|:.|              |.|.|:|:..:..         .|...:|.|||..:||.|:|
Yeast    98 AVDTAKLQMRRFILGTTEGDIKVLDSNFNLQREIDQ---------AHVSEITKLKFFPSGEALIS 153

  Fly    74 SSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSAAGLIASCSDDMTVRLWDARSKLCVKVLEGH 138
            ||.|..||:|.:......::|.||...|.|:|....|
Yeast   154 SSQDMQLKIWSVKDGSNPRTLIGHRATVTDIAIIDRG---------------------------- 190

  Fly   139 SRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDG 203
                        .|:| |.|.|.|:|||:..||.|:...:..::|                 :||
Yeast   191 ------------RNVL-SASLDGTIRLWECGTGTTIHTFNRKENP-----------------HDG 225

  Fly   204 L--VRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWN-YKKPKCMRTYRGH 265
            :  :.|:..:.    :.|.::.......::|...|:|:::..::..:.:.| :.|.:.::.
Yeast   226 VNSIALFVGTD----RQLHEISTSKKNNLEFGTYGKYVIAGHVSGVITVHNVFSKEQTIQL---- 282

  Fly   266 LNEFYCSNSNFSTTG--GIWIVSGSEDNTLCIWNLQTRE--LVQKISTEGDQILSTHCHPTANVI 326
            .::|.||.::.:..|  ..:|.:|.|:..|..|:|::.|  :.:.:..||..|.:.:....|..:
Yeast   283 PSKFTCSCNSLTVDGNNANYIYAGYENGMLAQWDLRSPECPVGEFLINEGTPINNVYFAAGALFV 347

  Fly   327 ASG 329
            :||
Yeast   348 SSG 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	61/289 (21%)
		WD40	49..341	CDD:238121	61/288 (21%)
		WD40 repeat	59..96	CDD:293791	15/36 (42%)
		WD40 repeat	102..137	CDD:293791	3/34 (9%)
		WD40 repeat	142..178	CDD:293791	12/35 (34%)
		WD40 repeat	185..220	CDD:293791	3/36 (8%)
		WD40 repeat	227..263	CDD:293791	5/36 (14%)
		WD40 repeat	271..309	CDD:293791	10/41 (24%)
		WD40 repeat	314..340	CDD:293791	4/16 (25%)
RPN14	NP_011511.3	WD40 repeat	96..133	CDD:293791	8/34 (24%)
		WD40	133..>357	CDD:421866	61/293 (21%)
		WD40 repeat	140..176	CDD:293791	15/35 (43%)
		WD40 repeat	181..217	CDD:293791	16/76 (21%)
		WD40 repeat	227..283	CDD:293791	7/63 (11%)
		WD40 repeat	290..328	CDD:293791	8/37 (22%)
		WD40 repeat	335..378	CDD:293791	4/16 (25%)
		WD40 repeat	385..412	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900