DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and SWD3

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_009734.1	Gene:	SWD3 / 852472	SGDID:	S000000379	Length:	315	Species:	Saccharomyces cerevisiae

Alignment Length:	303	Identity:	92/303 - (30%)
Similarity:	152/303 - (50%)	Gaps:	27/303 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 TGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSL-AGHGDGVNDVAWSAAG-LIASCSDDMTVR 122
            |..|.|.:|:.|..:.|..:| ::|::.....|:| ..|....:::.||..| .||:.|||.:|.
Yeast    17 TCAKISPDGQFLAITQGLNIL-IYDINRRTVSQTLVTSHARPFSELCWSPDGQCIATASDDFSVE 80

  Fly   123 LWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSV 187
            :......| :....||:....|..||.:.|||.::|.||::::||...|..:|.:.||.:.:.||
Yeast    81 IIHLSYGL-LHTFIGHTAPVISLTFNRKGNLLFTSSMDESIKIWDTLNGSLMKTISAHSEAVVSV 144

  Fly   188 DF-HRDGNIFVTSSYDGLVRLWDSSTGHVLKTLV-DVD------NIPVGYVKFSPNGRYILSSTL 244
            |. ..|.:|..:.|||||:|::|:.|||.||||. |.|      .:|:..||||.|.||:|..:|
Yeast   145 DVPMNDSSILSSGSYDGLIRIFDAETGHCLKTLTYDKDWKRENGVVPISQVKFSENARYLLVKSL 209

  Fly   245 NNTLRLWNYKKPKCMRTY------RGHLNEFYCSNSNFSTTGGI--WIVSGSEDNTLCIWNLQTR 301
            :..:::|:......:||:      :|.|:. .|.....:...|.  .::||.|:..:..||..|:
Yeast   210 DGVVKIWDCIGGCVVRTFQVQPLEKGVLHH-SCGMDFLNPEDGSTPLVISGYENGDIYCWNSDTK 273

  Fly   302 ELVQ----KISTEGDQILSTHCHPTANVIASGALQNSYAIKIW 340
            .|:|    .:......::|.||.  .|::.|.||.....:..|
Yeast   274 SLLQLLDGSLYHHSSPVMSIHCF--GNIMCSLALNGDCCLWRW 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	92/303 (30%)
		WD40	49..341	CDD:238121	92/303 (30%)
		WD40 repeat	59..96	CDD:293791	10/36 (28%)
		WD40 repeat	102..137	CDD:293791	10/35 (29%)
		WD40 repeat	142..178	CDD:293791	13/35 (37%)
		WD40 repeat	185..220	CDD:293791	18/35 (51%)
		WD40 repeat	227..263	CDD:293791	12/41 (29%)
		WD40 repeat	271..309	CDD:293791	10/43 (23%)
		WD40 repeat	314..340	CDD:293791	7/25 (28%)
SWD3	NP_009734.1	WD40	17..314	CDD:238121	91/301 (30%)
		WD40 repeat	17..53	CDD:293791	10/36 (28%)
		WD40 repeat	59..94	CDD:293791	10/35 (29%)
		WD40 repeat	99..135	CDD:293791	13/35 (37%)
		WD40 repeat	142..178	CDD:293791	18/35 (51%)
		WD40 repeat	192..228	CDD:293791	12/35 (34%)
		WD40 repeat	236..284	CDD:293791	11/48 (23%)
		WD40 repeat	290..312	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I1071
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46811
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.930