DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and WDR5b

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_192182.1	Gene:	WDR5b / 828189	AraportID:	AT4G02730	Length:	333	Species:	Arabidopsis thaliana

Alignment Length:	340	Identity:	137/340 - (40%)
Similarity:	211/340 - (62%)	Gaps:	23/340 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IETASTPGDSETEIAIPEAAFDSFKMPMLPSQFHLENSMSPGYAIKHSLLGHSGCVTGLKFSSNG 68
            :..|::.|::.|          |..:|:.....||:           :|.||:..::.:|||::|
plant    12 VANANSTGNAGT----------SGNVPIYKPYRHLK-----------TLEGHTAAISCVKFSNDG 55

  Fly    69 ENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKL-C 131
            ..|.|:|.|:.:.||..:....|....||..|::|:|||: :....|.|||.|:|:|||||.. |
plant    56 NLLASASVDKTMILWSATNYSLIHRYEGHSSGISDLAWSSDSHYTCSASDDCTLRIWDARSPYEC 120

  Fly   132 VKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIF 196
            :|||.||:.:.|...|||.:||:.|.|||||:|:|:|:|||.::::.||..||:||.|:|||::.
plant   121 LKVLRGHTNFVFCVNFNPPSNLIVSGSFDETIRIWEVKTGKCVRMIKAHSMPISSVHFNRDGSLI 185

  Fly   197 VTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRT 261
            |::|:||..::||:..|..||||:|..:..|.:.||||||::||.:||::||:|.||...|.::.
plant   186 VSASHDGSCKIWDAKEGTCLKTLIDDKSPAVSFAKFSPNGKFILVATLDSTLKLSNYATGKFLKV 250

  Fly   262 YRGHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVI 326
            |.||.|:.:|..|.||.|.|.:||||||||.:.:|:||.|.::|::....|.::|..|||..|.|
plant   251 YTGHTNKVFCITSAFSVTNGKYIVSGSEDNCVYLWDLQARNILQRLEGHTDAVISVSCHPVQNEI 315

  Fly   327 ASGALQNSYAIKIWK 341
            :|........|:|||
plant   316 SSSGNHLDKTIRIWK 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	128/294 (44%)
		WD40	49..341	CDD:238121	128/293 (44%)
		WD40 repeat	59..96	CDD:293791	11/36 (31%)
		WD40 repeat	102..137	CDD:293791	19/36 (53%)
		WD40 repeat	142..178	CDD:293791	18/35 (51%)
		WD40 repeat	185..220	CDD:293791	16/34 (47%)
		WD40 repeat	227..263	CDD:293791	17/35 (49%)
		WD40 repeat	271..309	CDD:293791	19/37 (51%)
		WD40 repeat	314..340	CDD:293791	8/25 (32%)
WDR5b	NP_192182.1	WD40	26..>330	CDD:225201	131/314 (42%)
		WD40	35..330	CDD:238121	130/305 (43%)
		WD40 repeat	46..83	CDD:293791	11/36 (31%)
		WD40 repeat	89..126	CDD:293791	19/36 (53%)
		WD40 repeat	131..167	CDD:293791	18/35 (51%)
		WD40 repeat	174..209	CDD:293791	16/34 (47%)
		WD40 repeat	216..252	CDD:293791	17/35 (49%)
		WD40 repeat	260..297	CDD:293791	19/36 (53%)
		WD40 repeat	303..329	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D957291at2759
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.790