DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10931 and Wsb1

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_062627.3	Gene:	Wsb1 / 78889	MGIID:	1926139	Length:	421	Species:	Mus musculus

Alignment Length:	365	Identity:	85/365 - (23%)
Similarity:	144/365 - (39%)	Gaps:	91/365 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EIAIPEAAFD------SFKMPMLPSQFHLENSMSPGYAI----------KHSLL------GHSGC 58
            |:..|.|.||      ::.:...|...:.  :.|.||.|          |:.||      .:|.|
Mouse    21 ELLAPAAPFDKKCGGENWTVAFAPDGSYF--AWSQGYRIVKLVPWSQCRKNFLLHGSKNVTNSSC 83

  Fly    59 VTGLKFSSNG-------ENLVSSSG------------------------------DRLL------ 80
            :...:.:|||       |:::....                              |:||
Mouse    84 LKLARQNSNGGQKNKPPEHVIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLN 148

  Fly    81 ----KLWDLSATRCIQSLAGHGDGVNDVAWSAAG--LIASCSDDMTVRLWDARSK-LCVKVLEGH 138
                |:||:...:.:.:|..|.:.|.|:.::..|  |:.|.|.|.|:|:||.:.. ..||||..|
Mouse   149 NGRIKIWDVYTGKLLLNLVDHIEMVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRAH 213

  Fly   139 SRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDG 203
            ..:.:||.|:|..::|.|....:.|.||::.....::.:..|...:.:.||..||.:..|:|||.
Mouse   214 QNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACDFSPDGALLATASYDT 278

  Fly   204 LVRLWDSSTGHVLKTLVDVDNIP------------VGYVKFSPNGRYILSSTLNNTLRLWNYKKP 256
            .|.:||...|.:|.....:...|            |..|.||.:|.::.|...:..:|.|...:
Mouse   279 RVYVWDPHNGDLLMEFGHLFPSPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKMVRFWRIDE- 342

  Fly   257 KCMRTYRGHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIW 296
            .|........|...|:   |||.|.: :.:|:.|.::..|
Mouse   343 DCPVQVAPLSNGLCCA---FSTDGSV-LAAGTHDGSVYFW 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	76/327 (23%)
		WD40	49..341	CDD:238121	75/316 (24%)
		WD40 repeat	59..96	CDD:293791	11/83 (13%)
		WD40 repeat	102..137	CDD:293791	14/37 (38%)
		WD40 repeat	142..178	CDD:293791	9/35 (26%)
		WD40 repeat	185..220	CDD:293791	13/34 (38%)
		WD40 repeat	227..263	CDD:293791	9/35 (26%)
		WD40 repeat	271..309	CDD:293791	8/26 (31%)
		WD40 repeat	314..340	CDD:293791
Wsb1	NP_062627.3	WD 1	124..165		6/40 (15%)
		WD40	135..388	CDD:238121	66/249 (27%)
		WD40	<139..382	CDD:225201	66/245 (27%)
		WD 2	168..208		12/39 (31%)
		WD40 repeat	174..212	CDD:293791	14/37 (38%)
		WD 3	212..251		10/38 (26%)
		WD40 repeat	217..253	CDD:293791	9/35 (26%)
		WD 4	254..293		14/38 (37%)
		WD40 repeat	261..299	CDD:293791	13/37 (35%)
		WD 5	309..346		9/37 (24%)
		WD40 repeat	314..353	CDD:293791	9/39 (23%)
		SOCS	382..420	CDD:295349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900