DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10931 and dcaf11

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001026845.1	Gene:	dcaf11 / 567578	ZFINID:	ZDB-GENE-050809-116	Length:	541	Species:	Danio rerio

Alignment Length:	365	Identity:	78/365 - (21%)
Similarity:	134/365 - (36%)	Gaps:	112/365 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELIETASTPGDSETEIAIPEAAFDSFKMPMLPSQFHLENSMSPGYAIKHSLLGHSGCVTGLKFSS 66
            :.|...|..||:||..|          :.:.|.:...                   ||..|..|:
Zfish   244 DYIHVCSVDGDNETHTA----------LDLNPDERRF-------------------CVFSLAAST 279

  Fly    67 NGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAW--SAAGLIASCSDDMTVRLWDARSK 129
            :|:.::..:.|..|.::|....:....:..|.|.||.||:  |::.|:.|.|||...::||.|:
Zfish   280 DGKEILGGANDGCLYVFDREQNKRTLKIDAHEDDVNAVAFADSSSQLLFSGSDDALCKVWDRRT- 343

  Fly   130 LCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVH--AHQDPITSVDFHRD 192
                                                  :|..:...:.|  .|:|.||.:....|
Zfish   344 --------------------------------------LREDRPQPVGHLAGHRDGITFIHSKGD 370

  Fly   193 GNIFVTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNY---- 253
            ....:::|.|..::|||..                   ||||. ..:.:|.|..|.:.|:|
Zfish   371 ARYLISNSKDQTIKLWDVR-------------------KFSPK-EGLAASRLAVTQQNWDYRWQQ 415

  Fly   254 ------KKPK-----CMRTYRGH--LNEFY-CSNSNFSTTGGIWIVSGSEDNTLCIWNLQTRELV 304
                  |:.|     .:.|||||  |:... |..|...:||..:|.:|.....:.|:::.|..:|
Zfish   416 VPQRALKRHKLTGDTSVMTYRGHGVLHTLIRCRFSPEFSTGQKFIYTGCSTGKIVIYDVLTGSVV 480

  Fly   305 QKISTEGDQILSTHCHPTANVIASGALQNSYAIKIWKSSE 344
            .|:|.....:.....||..|.:.|.:...  ||::|:.::
Zfish   481 CKLSNHDACVRDVSWHPYNNNMVSSSWDG--AIRLWEHTQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	69/314 (22%)
		WD40	49..341	CDD:238121	69/313 (22%)
		WD40 repeat	59..96	CDD:293791	7/36 (19%)
		WD40 repeat	102..137	CDD:293791	12/36 (33%)
		WD40 repeat	142..178	CDD:293791	1/35 (3%)
		WD40 repeat	185..220	CDD:293791	7/34 (21%)
		WD40 repeat	227..263	CDD:293791	12/50 (24%)
		WD40 repeat	271..309	CDD:293791	10/37 (27%)
		WD40 repeat	314..340	CDD:293791	6/25 (24%)
dcaf11	NP_001026845.1	WD40	175..515	CDD:225201	77/360 (21%)
		WD40	178..515	CDD:295369	77/360 (21%)
		WD40 repeat	225..265	CDD:293791	7/30 (23%)
		WD40 repeat	273..309	CDD:293791	6/35 (17%)
		WD40 repeat	314..356	CDD:293791	15/80 (19%)
		WD40 repeat	390..436	CDD:293791	12/46 (26%)
		WD40 repeat	448..474	CDD:293791	6/25 (24%)
		WD40 repeat	490..514	CDD:293791	6/25 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900