DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and wdr5

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_998264.1	Gene:	wdr5 / 406372	ZFINID:	ZDB-GENE-040426-2082	Length:	334	Species:	Danio rerio

Alignment Length:	332	Identity:	174/332 - (52%)
Similarity:	240/332 - (72%)	Gaps:	9/332 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 DSETEIAIPEAAFDSFKMPMLPSQFHLENSMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVSSSG 76
            |:|.....|.:|..:.:....|        :.|.|.:|.:|.||:..|:.:|||.:||.|.|||.
Zfish     9 DTEATKTQPASAASASQSKSAP--------VKPNYTLKFTLAGHTKAVSSVKFSPSGEWLASSSA 65

  Fly    77 DRLLKLWDLSATRCIQSLAGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKLCVKVLEGHSR 140
            |:|:|:|.....:..::::||..|::|||||: :.|:.|.|||.|:::||..|..|:|.|:|||.
Zfish    66 DKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130

  Fly   141 YSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLV 205
            |.|.|.||||:||:.|.||||:||:|||:|||.||.:.||.||:::|.|:|||::.|:||||||.
Zfish   131 YVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195

  Fly   206 RLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFY 270
            |:||:::|..||||:|.||.||.:|||||||:|||::||:|||:||:|.|.||::||.||.||.|
Zfish   196 RIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260

  Fly   271 CSNSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSY 335
            |..:|||.|||.|||||||||.:.||||||:|:|||:....|.::||.||||.|:|||.||:|..
Zfish   261 CIFANFSVTGGKWIVSGSEDNMVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDK 325

  Fly   336 AIKIWKS 342
            .||:|||
Zfish   326 TIKLWKS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	164/293 (56%)
		WD40	49..341	CDD:238121	164/292 (56%)
		WD40 repeat	59..96	CDD:293791	14/36 (39%)
		WD40 repeat	102..137	CDD:293791	17/35 (49%)
		WD40 repeat	142..178	CDD:293791	23/35 (66%)
		WD40 repeat	185..220	CDD:293791	19/34 (56%)
		WD40 repeat	227..263	CDD:293791	23/35 (66%)
		WD40 repeat	271..309	CDD:293791	26/37 (70%)
		WD40 repeat	314..340	CDD:293791	15/25 (60%)
wdr5	NP_998264.1	WD40	37..331	CDD:238121	164/293 (56%)
		WD40 repeat	48..85	CDD:293791	14/36 (39%)
		WD40 repeat	91..127	CDD:293791	17/35 (49%)
		WD40 repeat	132..168	CDD:293791	23/35 (66%)
		WD40 repeat	175..210	CDD:293791	19/34 (56%)
		WD40 repeat	217..253	CDD:293791	23/35 (66%)
		WD40 repeat	261..298	CDD:293791	26/36 (72%)
		WD40 repeat	304..330	CDD:293791	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581538
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D368256at33208
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.820