DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10931 and wdr13

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001018867.1	Gene:	wdr13 / 334827	ZFINID:	ZDB-GENE-050522-274	Length:	482	Species:	Danio rerio

Alignment Length:	342	Identity:	80/342 - (23%)
Similarity:	148/342 - (43%)	Gaps:	42/342 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 ENSMSPGYA---IKHSLLGH-SGCVTGLKFSSNGENLVS-SSGDRLLKLWDLS--ATRCIQSLAG 96
            :.::|..||   :.|....| ...|..|:|:::.::|:: .|.|..|.:..||  ......:|.|
Zfish   148 DTTLSENYAFAGMHHIFDQHVDSAVPRLQFANDDKHLLACCSLDGTLSIMTLSPPPPTVKVTLKG 212

  Fly    97 HGDGVNDVAWSAAG-LIASCSDDMTVRLWDARSKLCVK-VLEGHSRYSFSCCFNP-QANLLASTS 158
            |...|.|.|||.:. :|.|.|.|.|:|:|:.....|:: |::........|.|.| ..||....:
Zfish   213 HAGPVTDFAWSLSNDIIVSTSKDGTLRIWNTEDGRCIREVVDPEGSELLCCTFQPVNNNLTVVGN 277

  Fly   159 FDETVRLWDVRTGKTLKIVHAHQDPIT----SVDFHRDGNIFVTSSYDGLV--RLWDSSTGHVLK 217
            ..:.:::.::.|||.:|   .....:|    |:.|...|.|.......|.:  .|:|.:||.:.|
Zfish   278 SKQHLQVVNISTGKKVK---GGSSKLTGRVLSLSFDAPGRILWAGDDRGSIFSFLFDMATGKLTK 339

  Fly   218 T--LV-----DVDNIPV-GYVKFSPNGRYILSSTLNNTLRLW----NYKKPKCMRTY---RGH-- 265
            .  ||     .:.:|.. .::........:|.:...|.|.|:    |....:..|::   .|.
Zfish   340 AKRLVVNEGSSISSISARSWISREARDPSLLVNACVNKLLLYRVVDNEGTLQLKRSFPIQHGSQP 404

  Fly   266 LNEFYCSNSNFSTTGGIWIVSGSEDNTLCIWNLQ--TRELVQKISTEGDQILSTHCHPTANVIAS 328
            |:..:|...:|..  |..:|:||||..:..::::  |:.:|.|:......:|....:...:::||
Zfish   405 LHSIFCPLMSFRQ--GACVVTGSEDACVYFFDVERNTKAIVNKLQGHSGPVLDVSFNCDESLLAS 467

  Fly   329 GALQNSYAIKIWKSSEK 345
            .  ..|..:.||:..:|
Zfish   468 S--DASGMVIIWRREQK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	75/324 (23%)
		WD40	49..341	CDD:238121	75/323 (23%)
		WD40 repeat	59..96	CDD:293791	10/39 (26%)
		WD40 repeat	102..137	CDD:293791	13/36 (36%)
		WD40 repeat	142..178	CDD:293791	9/36 (25%)
		WD40 repeat	185..220	CDD:293791	11/42 (26%)
		WD40 repeat	227..263	CDD:293791	6/43 (14%)
		WD40 repeat	271..309	CDD:293791	11/39 (28%)
		WD40 repeat	314..340	CDD:293791	4/25 (16%)
wdr13	NP_001018867.1	WD40	<162..482	CDD:225201	76/326 (23%)
		WD40 repeat	173..212	CDD:293791	9/38 (24%)
		WD40	209..478	CDD:295369	64/275 (23%)
		WD40 repeat	217..253	CDD:293791	13/35 (37%)
		WD40 repeat	261..297	CDD:293791	9/38 (24%)
		WD40 repeat	304..400	CDD:293791	19/95 (20%)
		WD40 repeat	350..397	CDD:293791	7/46 (15%)
		WD40 repeat	408..447	CDD:293791	11/40 (28%)
		WD40 repeat	453..477	CDD:293791	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900