DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and Wdr5b

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001019937.1	Gene:	Wdr5b / 303907	RGDID:	1308567	Length:	328	Species:	Rattus norvegicus

Alignment Length:	306	Identity:	156/306 - (50%)
Similarity:	222/306 - (72%)	Gaps:	1/306 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LENSMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVN 102
            :|....|.||::.:|.|||..::.:|||.|||.|.||:.|.|:.:|.....:|.::|.||...::
  Rat    21 VEEPQKPNYALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLYGHSLEIS 85

  Fly   103 DVAWSA-AGLIASCSDDMTVRLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLW 166
            |||||: :..:.|.|||.|::|||.||..|:|.|:|||.:.|.|.|||.:||:.|.||||:|::|
  Rat    86 DVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSFDESVKIW 150

  Fly   167 DVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVK 231
            :|:|||.||.:.||.|||::|.||.:|::.|:.|||||.|:||:::|..|:||.|..|.||.:||
  Rat   151 EVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGNPPVSFVK 215

  Fly   232 FSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIW 296
            |||||:|||::||::||:||:|.:.:|::||.||.||.||..::||.||..|:|||||||.:.||
  Rat   216 FSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIFASFSVTGRKWVVSGSEDNMVYIW 280

  Fly   297 NLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSYAIKIWKS 342
            ||||:|:||::....|.::|..||||.|:|||.||:|...||||.|
  Rat   281 NLQTKEIVQRLQGHTDVVISAACHPTENIIASAALENDKTIKIWSS 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	150/293 (51%)
		WD40	49..341	CDD:238121	150/292 (51%)
		WD40 repeat	59..96	CDD:293791	14/36 (39%)
		WD40 repeat	102..137	CDD:293791	18/35 (51%)
		WD40 repeat	142..178	CDD:293791	20/35 (57%)
		WD40 repeat	185..220	CDD:293791	16/34 (47%)
		WD40 repeat	227..263	CDD:293791	20/35 (57%)
		WD40 repeat	271..309	CDD:293791	22/37 (59%)
		WD40 repeat	314..340	CDD:293791	14/25 (56%)
Wdr5b	NP_001019937.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		0/1 (0%)
		WD40	31..325	CDD:238121	150/293 (51%)
		WD40	<34..325	CDD:225201	150/290 (52%)
		WD 1	37..76		16/38 (42%)
		WD40 repeat	42..79	CDD:293791	14/36 (39%)
		WD 2	79..120		19/40 (48%)
		WD40 repeat	85..121	CDD:293791	18/35 (51%)
		WD 3	122..162		22/39 (56%)
		WD40 repeat	126..162	CDD:293791	20/35 (57%)
		WD 4	163..202		20/38 (53%)
		WD40 repeat	169..204	CDD:293791	16/34 (47%)
		DDB1-binding motif	186..190		3/3 (100%)
		WD 5	206..247		22/40 (55%)
		WD40 repeat	211..247	CDD:293791	20/35 (57%)
		WD 6	250..290		24/39 (62%)
		WD40 repeat	255..292	CDD:293791	22/36 (61%)
		WD 7	293..328		18/34 (53%)
		WD40 repeat	298..324	CDD:293791	14/25 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D368256at33208
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22847
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.820