DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and Wsb1

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001036026.1	Gene:	Wsb1 / 303336	RGDID:	1307835	Length:	421	Species:	Rattus norvegicus

Alignment Length:	368	Identity:	87/368 - (23%)
Similarity:	149/368 - (40%)	Gaps:	97/368 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EIAIPEAAFD------SFKMPMLPSQFHLENSMSPGYAI----------KHSLL------GHSGC 58
            |:..|.|.||      ::.:...|...:.  :.|.||.|          |:.||      .:|.|
  Rat    21 ELLAPAAPFDKKCGGENWTVAFAPDGSYF--AWSQGYRIVKLVPWSQCLKNFLLHGSKNVTNSSC 83

  Fly    59 VTGLKFSSNG-------ENLVSSSG------------------------------DRLL------ 80
            :...:.:|||       |:::....                              |:||
  Rat    84 LKLARQNSNGGQKNKPREHIIDCGDIVWSLAFGSSVPEKQSRCVNIEWHRFRFGQDQLLLATGLN 148

  Fly    81 ----KLWDLSATRCIQSLAGHGDGVNDVAWSAAG--LIASCSDDMTVRLWDARSK-LCVKVLEGH 138
                |:||:...:.:.:|..|.:.|.|:.::..|  |:.|.|.|.|:|:||.:.. ..||||.||
  Rat   149 NGRIKIWDVYTGKLLLNLVDHIEVVRDLTFAPDGSLLLVSASRDKTLRVWDLKDDGNMVKVLRGH 213

  Fly   139 SRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDG 203
            ..:.:||.|:|..::|.|....:.|.||::.....::.:..|...:.:.||..||.:..|:|||.
  Rat   214 QNWVYSCAFSPDCSMLCSVGASKAVFLWNMDKYTMIRRLEGHHHDVVACDFSPDGALLATASYDT 278

  Fly   204 LVRLWDSSTGHVLKTLVDVDNI-----P----------VGYVKFSPNGRYILSSTLNNTLRLWNY 253
            .|.:||.   |:..||::..::     |          |..|.||.:|.::.|...:..:|.|:.
  Rat   279 RVYVWDP---HIGDTLMEFGHLFPPPTPIFAGGANDRWVRAVSFSHDGLHVASLADDKMVRFWSI 340

  Fly   254 KKPKCMRTYRGHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIW 296
             ...|........|...|:   |||.|.: :.:|:.|.::..|
  Rat   341 -GDDCPVQVAPLSNGLCCA---FSTDGSV-LAAGTHDGSVYFW 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	78/330 (24%)
		WD40	49..341	CDD:238121	77/319 (24%)
		WD40 repeat	59..96	CDD:293791	11/83 (13%)
		WD40 repeat	102..137	CDD:293791	14/37 (38%)
		WD40 repeat	142..178	CDD:293791	9/35 (26%)
		WD40 repeat	185..220	CDD:293791	13/34 (38%)
		WD40 repeat	227..263	CDD:293791	9/35 (26%)
		WD40 repeat	271..309	CDD:293791	8/26 (31%)
		WD40 repeat	314..340	CDD:293791
Wsb1	NP_001036026.1	WD40	38..382	CDD:225201	82/351 (23%)
		WD40	135..388	CDD:238121	68/252 (27%)
		WD40 repeat	174..212	CDD:293791	14/37 (38%)
		WD40 repeat	217..253	CDD:293791	9/35 (26%)
		WD40 repeat	261..299	CDD:293791	14/40 (35%)
		WD40 repeat	314..353	CDD:293791	9/39 (23%)
		SOCS_WSB1_SWIP1	382..421	CDD:239715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900