DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and tup12

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_592910.2	Gene:	tup12 / 2543402	PomBaseID:	SPAC630.14c	Length:	598	Species:	Schizosaccharomyces pombe

Alignment Length:	359	Identity:	98/359 - (27%)
Similarity:	171/359 - (47%)	Gaps:	45/359 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ELIETASTPGDSETEIAIPEAAFDSFKMPMLPSQFHLENSMSP-GYAIKHSLLGHSGCVTGLKFS 65
            |:|.|::.|...|.:..:..               ::.|...| ...:.|: |.|:..:..::||
pombe   260 EIIPTSNVPNREEKDWTVTS---------------NVPNKEPPISVQLLHT-LEHTSVICYVRFS 308

  Fly    66 SNGENLVSSSGDRLLKLWDLSATRCI-----QSLAGHGD-GVNDVAWSAAG-LIASCSDDMTVRL 123
            ::|:.|.:.. :|...::::...:.|     :|....|| .|..||:|..| .:|:..:|..:|:
pombe   309 ADGKFLATGC-NRAAMVFNVETGKLITLLQEESSKREGDLYVRSVAFSPDGKYLATGVEDQQIRI 372

  Fly   124 WDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVD 188
            ||...|...::|.||.:..:|..|:.....|.|.|.|.||.||||..|:...|:|. .|.:|:|.
pombe   373 WDIAQKRVYRLLTGHEQEIYSLDFSKDGKTLVSGSGDRTVCLWDVEAGEQKLILHT-DDGVTTVM 436

  Fly   189 FHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWN- 252
            |..||......|.|.::|:|.|| |.:::.|...:. .|..|.|||:|:|::|.:|:||::||.
pombe   437 FSPDGQFIAAGSLDKVIRIWTSS-GTLVEQLHGHEE-SVYSVAFSPDGKYLVSGSLDNTIKLWEL 499

  Fly   253 ----------YKKPK-CMRTYRGHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQK 306
                      ||:.. |.:|:.|| .:|..|.:  .:..|.||:|||:|.|:..|:..:......
pombe   500 QCVSNVAPSMYKEGGICKQTFTGH-KDFILSVT--VSPDGKWIISGSKDRTIQFWSPDSPHSQLT 561

  Fly   307 ISTEGDQILSTHCHPTANVIASGALQNSYAIKIW 340
            :....:.::|....|..:..|:|:  .....:||
pombe   562 LQGHNNSVISVAVSPNGHCFATGS--GDLRARIW 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	91/312 (29%)
		WD40	49..341	CDD:238121	91/311 (29%)
		WD40 repeat	59..96	CDD:293791	7/41 (17%)
		WD40 repeat	102..137	CDD:293791	11/35 (31%)
		WD40 repeat	142..178	CDD:293791	14/35 (40%)
		WD40 repeat	185..220	CDD:293791	12/34 (35%)
		WD40 repeat	227..263	CDD:293791	17/47 (36%)
		WD40 repeat	271..309	CDD:293791	10/37 (27%)
		WD40 repeat	314..340	CDD:293791	4/25 (16%)
tup12	NP_592910.2	Tup_N	37..115	CDD:285748
		WD40	<284..598	CDD:225201	92/320 (29%)
		WD40	292..594	CDD:238121	91/312 (29%)
		WD40 repeat	302..338	CDD:293791	6/36 (17%)
		WD40 repeat	350..386	CDD:293791	11/35 (31%)
		WD40 repeat	391..426	CDD:293791	13/34 (38%)
		WD40 repeat	433..467	CDD:293791	12/34 (35%)
		WD40 repeat	473..521	CDD:293791	17/47 (36%)
		WD40 repeat	527..563	CDD:293791	10/37 (27%)
		WD40 repeat	569..593	CDD:293791	4/25 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.860