DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and tup11

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_592873.1	Gene:	tup11 / 2542299	PomBaseID:	SPAC18B11.10	Length:	614	Species:	Schizosaccharomyces pombe

Alignment Length:	309	Identity:	78/309 - (25%)
Similarity:	146/309 - (47%)	Gaps:	32/309 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDG--------VNDVAWSAA 109
            |.|...|..:|||:||:.|.:.. ::...::|:...:.:.:|  |.:.        |..:|:|..
pombe   310 LEHPSVVCCVKFSNNGKYLATGC-NQAANVFDVQTGKKLFTL--HEESPDPSRDLYVRTIAFSPD 371

  Fly   110 G-LIASCSDDMTVRLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKT 173
            | .:.:.::|..::|||..::....|..||.:..:|..|:.....:.|.|.|.|.|||||.||:.
pombe   372 GKYLVTGTEDRQIKLWDLSTQKVRYVFSGHEQDIYSLDFSHNGRFIVSGSGDRTARLWDVETGQC 436

  Fly   174 LKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRY 238
            :..:.. ::.:|::....:.......|.|.::|:| |.:|.:::.| :.....|..:.|||:...
pombe   437 ILKLEI-ENGVTAIAISPNDQFIAVGSLDQIIRVW-SVSGTLVERL-EGHKESVYSIAFSPDSSI 498

  Fly   239 ILSSTLNNTLRLWNYK----------KPK--CMRTYRGHLNEFYCSNSNFSTTGGIWIVSGSEDN 291
            :||.:|:.|:::|..:          ||:  |..||.|| .:|..|.:  .:....|.:|||:|.
pombe   499 LLSGSLDKTIKVWELQATRSVGLSAIKPEGICKATYTGH-TDFVLSVA--VSPDSRWGLSGSKDR 560

  Fly   292 TLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSYAIKIW 340
            ::..|:|||.:.........:.::|....|.....|||:  .....:||
pombe   561 SMQFWDLQTGQSYLTCQGHKNSVISVCFSPDGRQFASGS--GDLRARIW 607

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	78/309 (25%)
		WD40	49..341	CDD:238121	78/309 (25%)
		WD40 repeat	59..96	CDD:293791	9/36 (25%)
		WD40 repeat	102..137	CDD:293791	8/35 (23%)
		WD40 repeat	142..178	CDD:293791	13/35 (37%)
		WD40 repeat	185..220	CDD:293791	7/34 (21%)
		WD40 repeat	227..263	CDD:293791	13/47 (28%)
		WD40 repeat	271..309	CDD:293791	10/37 (27%)
		WD40 repeat	314..340	CDD:293791	5/25 (20%)
tup11	NP_592873.1	Tup_N	9..86	CDD:285748
		WD40	<303..610	CDD:225201	78/309 (25%)
		WD40	306..608	CDD:238121	78/309 (25%)
		WD40 repeat	316..358	CDD:293791	10/44 (23%)
		WD40 repeat	364..400	CDD:293791	8/35 (23%)
		WD40 repeat	405..441	CDD:293791	13/35 (37%)
		WD40 repeat	447..481	CDD:293791	8/35 (23%)
		WD40 repeat	487..535	CDD:293791	13/47 (28%)
		WD40 repeat	541..577	CDD:293791	10/37 (27%)
		WD40 repeat	583..607	CDD:293791	5/25 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	3	2.770