DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and wdr-5.2

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_510394.1	Gene:	wdr-5.2 / 181540	WormBaseID:	WBGene00010572	Length:	395	Species:	Caenorhabditis elegans

Alignment Length:	339	Identity:	158/339 - (46%)
Similarity:	221/339 - (65%)	Gaps:	12/339 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ASTPGDSETEIAIPEAAFDSFKMPM-LPSQFHLENSMSPGYAIKHSL-LGHSGCVTGLKFSSNGE 69
            ||||..|.|    |..::.|...|| .||..:|    .|.|.:...: ..|...::|:|||.:|.
Worm    64 ASTPMLSST----PGPSYSSAPTPMPNPSAANL----WPTYKLVAEIPNAHKKSISGIKFSPDGR 120

  Fly    70 NLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKLCVK 133
            .:.|.|.|..:|:|.:... ..::|.||..|:|:.:||: :.||.|||||..|:::|..|..|||
Worm   121 YMGSGSADCSIKIWRMDFV-YEKTLMGHRLGINEFSWSSDSKLIVSCSDDKLVKVFDVSSGRCVK 184

  Fly   134 VLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVT 198
            .|:||:.|.|.|||||...|:||.|||||:|:|..|.|.|:..:..|:||::||.|:|||....:
Worm   185 TLKGHTNYVFCCCFNPSGTLIASGSFDETIRIWCARNGNTIFSIPGHEDPVSSVCFNRDGAYLAS 249

  Fly   199 SSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYR 263
            .||||:||:|||:||..:|||:|.::.|:.:|||||||:|||:|.|||||:||:|:|.:.::.|.
Worm   250 GSYDGIVRIWDSTTGTCVKTLIDEEHPPITHVKFSPNGKYILASNLNNTLKLWDYQKLRVLKEYT 314

  Fly   264 GHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIAS 328
            ||.|..||..:|||.|||.||||||||:.:.||||||||::|.:......::.|.|||..|:|||
Worm   315 GHENSKYCVAANFSVTGGKWIVSGSEDHKVYIWNLQTREILQTLDGHNTAVMCTDCHPGQNIIAS 379

  Fly   329 GALQNSYAIKIWKS 342
            .||:....||||:|
Worm   380 AALEPDMRIKIWRS 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	141/294 (48%)
		WD40	49..341	CDD:238121	141/293 (48%)
		WD40 repeat	59..96	CDD:293791	11/36 (31%)
		WD40 repeat	102..137	CDD:293791	17/35 (49%)
		WD40 repeat	142..178	CDD:293791	19/35 (54%)
		WD40 repeat	185..220	CDD:293791	19/34 (56%)
		WD40 repeat	227..263	CDD:293791	20/35 (57%)
		WD40 repeat	271..309	CDD:293791	24/37 (65%)
		WD40 repeat	314..340	CDD:293791	12/25 (48%)
wdr-5.2	NP_510394.1	WWbp	<1..87	CDD:304964	10/26 (38%)
		WD40	<104..395	CDD:225201	143/291 (49%)
		WD40	106..392	CDD:238121	141/286 (49%)
		WD40 repeat	110..146	CDD:293791	11/36 (31%)
		WD40 repeat	152..188	CDD:293791	17/35 (49%)
		WD40 repeat	193..229	CDD:293791	19/35 (54%)
		WD40 repeat	236..271	CDD:293791	19/34 (56%)
		WD40 repeat	278..314	CDD:293791	20/35 (57%)
		WD40 repeat	322..359	CDD:293791	24/36 (67%)
		WD40 repeat	365..391	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D368256at33208
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100268
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.690