DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and wdr-5.3

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_001024299.1	Gene:	wdr-5.3 / 179489	WormBaseID:	WBGene00013862	Length:	501	Species:	Caenorhabditis elegans

Alignment Length:	338	Identity:	141/338 - (41%)
Similarity:	219/338 - (64%)	Gaps:	11/338 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 STPGDSETEIAIPEAAFDSFKMPMLPSQFHLENSMSP---GYAIKHSLLGHSGCVTGLKFSSNGE 69
            :|...|..::|.|       :.|:.|:......:..|   .:::..::.||:..|:.:|||..|:
Worm   169 TTKPTSTIQVAPP-------RDPVAPTTSSSGITKKPENGEFSLVKTISGHTKSVSVIKFSYCGK 226

  Fly    70 NLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKLCVK 133
            .|.:.|.|:.:|:|:......:|:||.|..|:||.:||: :..|||.|||.||:::|..|..|::
Worm   227 YLGTGSADKQIKVWNTVDMTYLQTLASHQLGINDFSWSSNSQFIASASDDTTVKIFDVISGACLR 291

  Fly   134 VLEGHSRYSFSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVT 198
            .:.||:.|.|.|.||||::|:||..||||||:||.:||..:|.:.||.|||||:.::.|||...|
Worm   292 TMRGHTNYVFCCSFNPQSSLIASAGFDETVRVWDFKTGLCVKCIPAHSDPITSISYNHDGNTMAT 356

  Fly   199 SSYDGLVRLWDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYR 263
            |||||.:|:||:::|..||||||.|:.||.:|.|||||:|:||:.|:::|:||:.||.|.::.|.
Worm   357 SSYDGCIRVWDAASGSCLKTLVDTDHAPVTFVCFSPNGKYLLSAQLDSSLKLWDPKKAKPLKYYN 421

  Fly   264 GHLNEFYCSNSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIAS 328
            ||.|:.||..:|.|...|..|:|||||..:.:|::||:::||.:......:|:|..|||.|:|||
Worm   422 GHKNKKYCLFANMSVPLGKHIISGSEDGRILVWSIQTKQIVQILEGHTTPVLATDSHPTLNIIAS 486

  Fly   329 GALQNSYAIKIWK 341
            |.|:....|:||:
Worm   487 GGLEPDNVIRIWR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	133/293 (45%)
		WD40	49..341	CDD:238121	133/292 (46%)
		WD40 repeat	59..96	CDD:293791	12/36 (33%)
		WD40 repeat	102..137	CDD:293791	15/35 (43%)
		WD40 repeat	142..178	CDD:293791	20/35 (57%)
		WD40 repeat	185..220	CDD:293791	18/34 (53%)
		WD40 repeat	227..263	CDD:293791	17/35 (49%)
		WD40 repeat	271..309	CDD:293791	15/37 (41%)
		WD40 repeat	314..340	CDD:293791	12/25 (48%)
wdr-5.3	NP_001024299.1	WD40	<200..501	CDD:225201	134/300 (45%)
		WD40	205..499	CDD:238121	133/293 (45%)
		WD40 repeat	216..253	CDD:293791	12/36 (33%)
		WD40 repeat	259..295	CDD:293791	15/35 (43%)
		WD40 repeat	300..336	CDD:293791	20/35 (57%)
		WD40 repeat	343..378	CDD:293791	18/34 (53%)
		WD40 repeat	385..421	CDD:293791	17/35 (49%)
		WD40 repeat	429..466	CDD:293791	15/36 (42%)
		WD40 repeat	472..498	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157524
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D368256at33208
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850