DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and wdr-5.1

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_497749.1	Gene:	wdr-5.1 / 175474	WormBaseID:	WBGene00006474	Length:	376	Species:	Caenorhabditis elegans

Alignment Length:	379	Identity:	155/379 - (40%)
Similarity:	230/379 - (60%)	Gaps:	42/379 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MELIETASTPGDSETEIAIPEAAFDSFKMP-------MLPSQFHLENSMSP-------------- 44
            |:..|.|::..:.:     |....|...:|       ..|:.....||:||
Worm     1 MDTSENAASAAEQQ-----PTQQIDQLTVPNAPDGGSSAPAPSTSPNSISPSNPTGTPAPGASAQ 60

  Fly    45 ---------------GYAIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSL 94
                           .|.:..:|.||:..::..|||..|:.|.:||.|:.:|:|::....|.::|
Worm    61 TPNPNAAGASASGSANYKLMCTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTL 125

  Fly    95 AGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTS 158
            .||..||||:|||: :..:.|.|||.|:::::..:....|.|:||:.|.|.|.||||::|:.|.|
Worm   126 TGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGS 190

  Fly   159 FDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDVD 223
            |||:||:|||:||..:|.:.||.||:::|.|:|||::..:.|||||||:||::.|..:|||||.:
Worm   191 FDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDDE 255

  Fly   224 NIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCSNSNFSTTGGIWIVSGS 288
            |.||.:|||||||:|||:|.|::||:||::.|.|.::.|.||.|..||..:|||.|||.||:|||
Worm   256 NPPVAFVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTGHENSKYCIFANFSVTGGKWIISGS 320

  Fly   289 EDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSYAIKIWKS 342
            ||..:.||||||||:||.:......:|::.|||..|:||||||:....|.||:|
Worm   321 EDCKIYIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASGALEPDNKIHIWRS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	141/293 (48%)
		WD40	49..341	CDD:238121	141/292 (48%)
		WD40 repeat	59..96	CDD:293791	12/36 (33%)
		WD40 repeat	102..137	CDD:293791	12/35 (34%)
		WD40 repeat	142..178	CDD:293791	20/35 (57%)
		WD40 repeat	185..220	CDD:293791	17/34 (50%)
		WD40 repeat	227..263	CDD:293791	19/35 (54%)
		WD40 repeat	271..309	CDD:293791	24/37 (65%)
		WD40 repeat	314..340	CDD:293791	12/25 (48%)
wdr-5.1	NP_497749.1	WD40	<76..372	CDD:225201	141/295 (48%)
		WD40	79..373	CDD:238121	141/293 (48%)
		WD40 repeat	90..127	CDD:293791	12/36 (33%)
		WD40 repeat	133..169	CDD:293791	12/35 (34%)
		WD40 repeat	174..210	CDD:293791	20/35 (57%)
		WD40 repeat	217..252	CDD:293791	17/34 (50%)
		WD40 repeat	259..295	CDD:293791	19/35 (54%)
		WD40 repeat	303..340	CDD:293791	24/36 (67%)
		WD40 repeat	346..372	CDD:293791	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157522
Domainoid	1	1.000	49	1.000	Domainoid score	I8000
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D368256at33208
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.820