Protein Alignment CG10931 and DAW1

DIOPT Version :10

• Sequence 1: NP_611261.1
• Gene: CG10931 / 37024
• FlyBaseID: FBgn0034274
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_849143.1
• Gene: DAW1 / 164781
• HGNCID: 26383
• Length: 415
• Species: Homo sapiens
• Alignment Length: 352
• Identity: 93/352 - (26%)
• Similarity: 158/352 - (44%)
• Gaps: 61/352 - (17%)

  Fly    39 ENSMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVSSSGDRLLKLWDLSATRCIQSLAGHGDGVND 103
            :||....|..| .|..|...:|.:..:.:|...::.|.||..||||.::...:.:|.||.:.|..
Human    76 QNSNHTFYLFK-VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYA 139

  Fly   104 VAWS--AAGLIASCSDDMTVRLWDARSKLCVKVLEGHSRYSFSCCFNPQANLLASTSFDETVRLW 166
            :|::  ....||:.|.|.|.:||...:..|.....||:.......||||:.|:|:.|.|.|.:||
Human   140 IAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204

  Fly   167 DVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRLWDSSTGHVLKTLVDVDNIPVGY-- 229
            |::.|:.:..:..|...|.|:.|:..|:..:|.|:|..|.:||:.||..:       ||.:|:
Human   205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKV-------NILIGHCA 262

  Fly   230 ----VKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCSNSNFSTTG---------- 280
                ..|:.:...||:.:::.|.:||:....||:.|..||.:|..  :|.|..||
Human   263 EISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEIL--DSCFDYTGKLIATASADG 325

  Fly   281 -------------------------------GIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQI 314
                                           |..:::||.|.|..||:.||.:.:|.:....|:|
Human   326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI 390

  Fly   315 LSTHCHPTANVIASGALQNSYAIKIWK 341
            .|...:...|::.:|:..|:  .:||:
Human   391 FSCAFNYKGNIVITGSKDNT--CRIWR 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<47..340	CDD:441893	88/341 (26%)
		WD40 repeat	59..96	CDD:293791	10/36 (28%)
		WD40 repeat	102..137	CDD:293791	9/36 (25%)
		WD40 repeat	142..178	CDD:293791	13/35 (37%)
		WD40 repeat	185..220	CDD:293791	11/34 (32%)
		WD40 repeat	227..263	CDD:293791	10/41 (24%)
		WD40 repeat	271..309	CDD:293791	14/78 (18%)
		WD40 repeat	314..340	CDD:293791	5/25 (20%)
DAW1	NP_849143.1	WD40	87..415	CDD:441893	88/338 (26%)
		WD 1	90..129		10/38 (26%)
		WD40 repeat	96..132	CDD:293791	10/35 (29%)
		WD 2	132..174		12/41 (29%)
		WD40 repeat	137..175	CDD:293791	10/37 (27%)
		WD 3	175..214		15/38 (39%)
		WD40 repeat	181..217	CDD:293791	13/35 (37%)
		WD 4	217..256		13/45 (29%)
		WD40 repeat	222..258	CDD:293791	14/42 (33%)
		WD 5	259..298		9/38 (24%)
		WD40 repeat	265..300	CDD:293791	9/34 (26%)
		WD 6	301..340		7/40 (18%)
		WD40 repeat	306..342	CDD:293791	4/37 (11%)
		WD 7	343..384		10/40 (25%)
		WD40 repeat	348..384	CDD:293791	10/35 (29%)
		WD 8	386..415		7/30 (23%)
		WD40 repeat	390..414	CDD:293791	5/25 (20%)