DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and Wdr5

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	NP_543124.1	Gene:	Wdr5 / 140858	MGIID:	2155884	Length:	334	Species:	Mus musculus

Alignment Length:	330	Identity:	177/330 - (53%)
Similarity:	240/330 - (72%)	Gaps:	7/330 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ETEIAIPEAAFDSFKMPMLPSQFHLENSMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVSSSGDR 78
            |||.|..:....|......|:      .:.|.||:|.:|.||:..|:.:|||.|||.|.|||.|:
Mouse     9 ETEAARAQPTPSSSATQSKPT------PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK 67

  Fly    79 LLKLWDLSATRCIQSLAGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKLCVKVLEGHSRYS 142
            |:|:|.....:..::::||..|::|||||: :.|:.|.|||.|:::||..|..|:|.|:|||.|.
Mouse    68 LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132

  Fly   143 FSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRL 207
            |.|.||||:||:.|.||||:||:|||:|||.||.:.||.||:::|.|:|||::.|:||||||.|:
Mouse   133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197

  Fly   208 WDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCS 272
            ||:::|..||||:|.||.||.:|||||||:|||::||:|||:||:|.|.||::||.||.||.||.
Mouse   198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262

  Fly   273 NSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSYAI 337
            .:|||.|||.|||||||||.:.||||||:|:|||:....|.::||.||||.|:|||.||:|...|
Mouse   263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

  Fly   338 KIWKS 342
            |:|||
Mouse   328 KLWKS 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	165/293 (56%)
		WD40	49..341	CDD:238121	165/292 (57%)
		WD40 repeat	59..96	CDD:293791	15/36 (42%)
		WD40 repeat	102..137	CDD:293791	17/35 (49%)
		WD40 repeat	142..178	CDD:293791	23/35 (66%)
		WD40 repeat	185..220	CDD:293791	19/34 (56%)
		WD40 repeat	227..263	CDD:293791	23/35 (66%)
		WD40 repeat	271..309	CDD:293791	26/37 (70%)
		WD40 repeat	314..340	CDD:293791	15/25 (60%)
Wdr5	NP_543124.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		6/27 (22%)
		WD40	37..331	CDD:238121	165/293 (56%)
		WD 1	43..82		17/38 (45%)
		WD40 repeat	48..85	CDD:293791	15/36 (42%)
		WD 2	85..126		19/40 (48%)
		WD40 repeat	91..127	CDD:293791	17/35 (49%)
		WD 3	128..168		26/39 (67%)
		WD40 repeat	132..168	CDD:293791	23/35 (66%)
		WD 4	169..208		21/38 (55%)
		WD40 repeat	175..210	CDD:293791	19/34 (56%)
		WD 5	212..253		26/40 (65%)
		WD40 repeat	217..253	CDD:293791	23/35 (66%)
		WD 6	256..296		27/39 (69%)
		WD40 repeat	261..298	CDD:293791	26/36 (72%)
		WD 7	299..333		19/34 (56%)
		WD40 repeat	304..330	CDD:293791	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837786
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D957291at2759
OrthoFinder	1	1.000	-	-		FOG0002159
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22847
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.820