Protein Alignment CG10931 and WDR5

DIOPT Version :10

• Sequence 1: NP_611261.1
• Gene: CG10931 / 37024
• FlyBaseID: FBgn0034274
• Length: 345
• Species: Drosophila melanogaster
• Sequence 2: NP_060058.1
• Gene: WDR5 / 11091
• HGNCID: 12757
• Length: 334
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 177/330 - (53%)
• Similarity: 240/330 - (72%)
• Gaps: 7/330 - (2%)

  Fly    14 ETEIAIPEAAFDSFKMPMLPSQFHLENSMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVSSSGDR 78
            |||.|..:....|......|:      .:.|.||:|.:|.||:..|:.:|||.|||.|.|||.|:
Human     9 ETEAARAQPTPSSSATQSKPT------PVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADK 67

  Fly    79 LLKLWDLSATRCIQSLAGHGDGVNDVAWSA-AGLIASCSDDMTVRLWDARSKLCVKVLEGHSRYS 142
            |:|:|.....:..::::||..|::|||||: :.|:.|.|||.|:::||..|..|:|.|:|||.|.
Human    68 LIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYV 132

  Fly   143 FSCCFNPQANLLASTSFDETVRLWDVRTGKTLKIVHAHQDPITSVDFHRDGNIFVTSSYDGLVRL 207
            |.|.||||:||:.|.||||:||:|||:|||.||.:.||.||:::|.|:|||::.|:||||||.|:
Human   133 FCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRI 197

  Fly   208 WDSSTGHVLKTLVDVDNIPVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGHLNEFYCS 272
            ||:::|..||||:|.||.||.:|||||||:|||::||:|||:||:|.|.||::||.||.||.||.
Human   198 WDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262

  Fly   273 NSNFSTTGGIWIVSGSEDNTLCIWNLQTRELVQKISTEGDQILSTHCHPTANVIASGALQNSYAI 337
            .:|||.|||.|||||||||.:.||||||:|:|||:....|.::||.||||.|:|||.||:|...|
Human   263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTI 327

  Fly   338 KIWKS 342
            |:|||
Human   328 KLWKS 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<47..340	CDD:441893	166/293 (57%)
		WD40 repeat	59..96	CDD:293791	15/36 (42%)
		WD40 repeat	102..137	CDD:293791	17/35 (49%)
		WD40 repeat	142..178	CDD:293791	23/35 (66%)
		WD40 repeat	185..220	CDD:293791	19/34 (56%)
		WD40 repeat	227..263	CDD:293791	23/35 (66%)
		WD40 repeat	271..309	CDD:293791	26/37 (70%)
		WD40 repeat	314..340	CDD:293791	15/25 (60%)
WDR5	NP_060058.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		6/27 (22%)
		WD40	<36..330	CDD:441893	166/293 (57%)
		WD 1	43..82		17/38 (45%)
		WD40 repeat	48..85	CDD:293791	15/36 (42%)
		WD 2	85..126		19/40 (48%)
		WD40 repeat	91..127	CDD:293791	17/35 (49%)
		WD 3	128..168		26/39 (67%)
		WD40 repeat	132..168	CDD:293791	23/35 (66%)
		WD 4	169..208		21/38 (55%)
		WD40 repeat	175..210	CDD:293791	19/34 (56%)
		WD 5	212..253		26/40 (65%)
		WD40 repeat	217..253	CDD:293791	23/35 (66%)
		WD 6	256..296		27/39 (69%)
		WD40 repeat	261..298	CDD:293791	26/36 (72%)
		WD 7	299..333		19/34 (56%)
		WD40 repeat	304..330	CDD:293791	15/25 (60%)