DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10931 and wdr90

DIOPT Version :9

Sequence 1:	NP_611261.1	Gene:	CG10931 / 37024	FlyBaseID:	FBgn0034274	Length:	345	Species:	Drosophila melanogaster
Sequence 2:	XP_003201394.2	Gene:	wdr90 / 100038787	ZFINID:	ZDB-GENE-070424-67	Length:	1843	Species:	Danio rerio

Alignment Length:	402	Identity:	82/402 - (20%)
Similarity:	143/402 - (35%)	Gaps:	127/402 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SMSPGYAIKHSLLGHSGCVTGLKFSSNGENLVS--SSGDRLLKLWDLSATRCIQSLAGHGDGVND 103
            ||:.....:...:||:..|:.|..:::...|.|  :..:.|::||..||..|...:..|...:|.
Zfish   439 SMTVSSGQQRFFIGHTDKVSALALNASSTVLASAQTGTNSLIRLWSYSAGVCQTIIPTHTHALNL 503

  Fly   104 VAWS-AAGLIASCSDD----MTVRLWDAR---SKLCVKVL-EGHSRYSFSCCFNPQANLLASTSF 159
            :::| :.|::.....|    .||.||:.|   ....|.|| :.|:        :.....:....|
Zfish   504 LSFSHSGGVLCGVGKDSHNKTTVVLWNTRHVTDGSVVPVLAKAHT--------DVDIQTIKIAFF 560

  Fly   160 DET---------VRLWDVRTG----------------------------------KTLKIVHAHQ 181
            |:|         ||||.||.|                                  :|| .|.:..
Zfish   561 DDTRMVSCGSGNVRLWRVRGGSLRSCPVNLGQYHNLEFTDLAFEQGHTQNRPVDDRTL-FVSSRS 624

  Fly   182 DPITSVDF--------------------HRDGNIF------------------VTSSYDGLVRLW 208
            ..|..:|:                    .|:...|                  ||.|.||.:|||
Zfish   625 GHILEIDYVAVAIKNIRRLLPAHESHTHQREKQTFSTGAGIAVNSISVCAKFCVTGSEDGFMRLW 689

  Fly   209 DSSTGHVLKTLVDVDNI--------PVGYVKFSPNGRYILSSTLNNTLRLWNYKKPKCMRTYRGH 265
            .          :|..::        ||..|..|.:|..:|::|....|...:.    ..|.||..
Zfish   690 P----------LDFSSVFLEAEHEGPVSLVNVSSDGSRVLAATSTGNLGYLDV----ASRGYRTL 740

  Fly   266 LNEFYCSNSNFSTTG-GIWIVSGSEDNTLCIWNLQT-RELVQKISTEGDQILSTHCHPTANVIAS 328
            :.....|...||..| ...:.:.|.|.|:.:|::.| ::|...::.:.:...|...||:..:.|.
Zfish   741 MRSHTASVLGFSVDGVRRRVTTVSRDATVRVWDMDTLQQLYDFVTDDDENPCSVAFHPSMPLFAC 805

  Fly   329 GALQNSYAIKIW 340
            |:  :|.|::::
Zfish   806 GS--SSGAVRVF 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10931	NP_611261.1	WD40	<48..341	CDD:225201	80/395 (20%)
		WD40	49..341	CDD:238121	80/394 (20%)
		WD40 repeat	59..96	CDD:293791	10/38 (26%)
		WD40 repeat	102..137	CDD:293791	12/43 (28%)
		WD40 repeat	142..178	CDD:293791	12/78 (15%)
		WD40 repeat	185..220	CDD:293791	11/72 (15%)
		WD40 repeat	227..263	CDD:293791	8/35 (23%)
		WD40 repeat	271..309	CDD:293791	10/39 (26%)
		WD40 repeat	314..340	CDD:293791	7/25 (28%)
wdr90	XP_003201394.2	DUF667	7..197	CDD:282825
		WD40	302..790	CDD:225201	75/373 (20%)
		WD40	<450..689	CDD:295369	49/247 (20%)
		WD40 repeat	457..495	CDD:293791	10/37 (27%)
		WD40 repeat	502..536	CDD:293791	9/33 (27%)
		WD40 repeat	552..594	CDD:293791	10/41 (24%)
		WD40	670..1000	CDD:295369	37/162 (23%)
		WD40 repeat	670..701	CDD:293791	9/40 (23%)
		WD40 repeat	707..742	CDD:293791	9/38 (24%)
		WD40 repeat	746..784	CDD:293791	10/37 (27%)
		WD40 repeat	792..827	CDD:293791	7/26 (27%)
		WD40	818..1330	CDD:225201
		WD40 repeat	833..869	CDD:293791
		WD40 repeat	933..969	CDD:293791
		WD40	965..1314	CDD:295369
		WD40 repeat	976..1013	CDD:293791
		WD40 repeat	1211..1245	CDD:293791
		WD40	<1214..1574	CDD:225201
		WD40	1241..1557	CDD:295369
		WD40 repeat	1251..1292	CDD:293791
		WD40 repeat	1297..1365	CDD:293791
		WD40 repeat	1392..1426	CDD:293791
		WD40 repeat	1480..1528	CDD:293791
		WD40	1491..1790	CDD:295369
		WD40	1519..>1841	CDD:225201
		WD40 repeat	1533..1569	CDD:293791
		WD40 repeat	1576..1619	CDD:293791
		WD40 repeat	1625..1661	CDD:293791
		WD40 repeat	1668..1717	CDD:293791
		WD40 repeat	1777..1809	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0266
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810