DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-A and ALG2

DIOPT Version :9

Sequence 1:	NP_001286547.1	Gene:	PIG-A / 37020	FlyBaseID:	FBgn0034270	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_011450.1	Gene:	ALG2 / 852815	SGDID:	S000003033	Length:	503	Species:	Saccharomyces cerevisiae

Alignment Length:	546	Identity:	104/546 - (19%)
Similarity:	184/546 - (33%)	Gaps:	175/546 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FFYP--SIGGVEEHVYNLSQMLLSLGHKIVVLT------HAYGDCSGIRYVTGYLKVY----YLP 61
            |.:|  .|||.|..|.:.:..|...||.:::.|      |.:.:..     .|.|||.    :||
Yeast    11 FIHPDLGIGGAERLVVDAALGLQQQGHSVIIYTSHCDKSHCFEEVK-----NGQLKVEVYGDFLP 70

  Fly    62 IKVCYNQCILPTAVCNVPMLRAVLLRERVEVVHGHSAFSALAHEALMVGSL---LGLKTVFTDHS 123
            ........|:...:..:.::..::|:::|.           |::.:::..|   :.|..:|:..:
Yeast    71 TNFLGRFFIVFATIRQLYLVIQLILQKKVN-----------AYQLIIIDQLSTCIPLLHIFSSAT 124

  Fly   124 LFGFADLSAALTNNLLEVNLGMVNHAICVSHIGKENTVLRA---RVAKHRVSVIPNAVDTALFTP 185
            |..:..    ..:.||....|::            ..:.|.   .:.:..||.....|..:.||.
Yeast   125 LMFYCH----FPDQLLAQRAGLL------------KKIYRLPFDLIEQFSVSAADTVVVNSNFTK 173

  Fly   186 ------------DPQQ-RPSNDIINIVVAS------RLVYRKGIDLLAGIIPRFKN--------- 222
                        ||.. .|..|:..|.:..      :.|:.:| |.....|.||:.
Yeast   174 NTFHQTFKYLSNDPDVIYPCVDLSTIEIEDIDKKFFKTVFNEG-DRFYLSINRFEKKKDVALAIK 237

  Fly   223 ---------TPNINFIIVGDGPKR--DLLEEIREKTNMQERVQM----VGAVEHNRVRD------ 266
                     ..|:..:|.|...:|  :.:|.::|..::.:..::    :...|..||.|
Yeast   238 AFALSEDQINDNVKLVICGGYDERVAENVEYLKELQSLADEYELSHTTIYYQEIKRVSDLESFKT 302

  Fly   267 ------------------FLVRGHIFLNTSLTEAYCMAIVEAASCGLQVVSTSVGGIPEVLPKSL 313
                              .|.|..:.|.|...|.:.:..:||...|..|::.:.||..|.: ||.
Yeast   303 NNSKIIFLTSISSSLKELLLERTEMLLYTPAYEHFGIVPLEAMKLGKPVLAVNNGGPLETI-KSY 366

  Fly   314 ILLAEPEIDA---IYAAILI----AIDRHRKSSFKVSPSVGNGHLASDANG--KVKRRRRRKVDT 369
            : ..|.|..|   :..|:.|    |||..||       .:.||.:..:.||  :||:...|:..|
Yeast   367 V-AGENESSATGWLKPAVPIQWATAIDESRK-------ILQNGSVNFERNGPLRVKKYFSREAMT 423

  Fly   370 PISPTQLPAVSAPPADQNSSTEPVMCPYRCNELVETLYNWEDVALRTVKVYDRVLNERSFTTSEL 434
                              .|.|.               |.|.|..:..|.|...:...||:...|
Yeast   424 ------------------QSFEE---------------NVEKVIWKEKKYYPWEIFGISFSNFIL 455

  Fly   435 VFA---VWQHGSW---FLVFFVVAHF 454
            ..|   :..:..|   |:..|:|.:|
Yeast   456 HMAFIKILPNNPWPFLFMATFMVLYF 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-A	NP_001286547.1	RfaB	1..309	CDD:223515	68/384 (18%)
PIG-A	NP_001286547.1	GT1_PIG-A_like	2..451	CDD:99970	102/541 (19%)
ALG2	NP_011450.1	GT4_ALG2-like	7..426	CDD:340834	88/474 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810