DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIG-A and SETH2

DIOPT Version :9

Sequence 1:	NP_001286547.1	Gene:	PIG-A / 37020	FlyBaseID:	FBgn0034270	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001326667.1	Gene:	SETH2 / 823646	AraportID:	AT3G45100	Length:	447	Species:	Arabidopsis thaliana

Alignment Length:	479	Identity:	223/479 - (46%)
Similarity:	297/479 - (62%)	Gaps:	62/479 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRICMVSDFFYPSIGGVEEHVYNLSQMLLSLGHKIVVLTHAYGDCSGIRYVTGYLKVYYLPIKVC 65
            :|:.||||||:|:.||||.|:|.|||.||.||||:||:|||||:.||:||:||.|||||:|.:..
plant     7 LRVLMVSDFFFPNFGGVENHIYYLSQCLLKLGHKVVVMTHAYGNRSGVRYMTGGLKVYYVPWRPF 71

  Fly    66 YNQCILPTAVCNVPMLRAVLLRERVEVVHGHSAFSALAHEALMVGSLLGLKTVFTDHSLFGFADL 130
            ..|...||....:|::|.:|.||::.|||||.|||.|.|||||....:|.|.|||||||:||||:
plant    72 VMQTTFPTVYGTLPIVRTILRREKITVVHGHQAFSTLCHEALMHARTMGYKVVFTDHSLYGFADV 136

  Fly   131 SAALTNNLLEVNLGMVNHAICVSHIGKENTVLRARVAKHRVSVIPNAVDTALFTPDPQQRPSNDI 195
            .:...|.:|:.:|..::.||||||..|||||||:.::..:|.:||||||||:|.| ...|||.||
plant   137 GSIHMNKVLQFSLADIDQAICVSHTSKENTVLRSGLSPAKVFMIPNAVDTAMFKP-ASVRPSTDI 200

  Fly   196 INIVVASRLVYRKGIDLLAGIIPRF-KNTPNINFIIVGDGPKRDLLEEIREKTNMQERVQMVGAV 259
            |.|||.||||||||.|||..:||.. :..||:.|::.|||||...|||:|||.::|:||:|:|||
plant   201 ITIVVISRLVYRKGADLLVEVIPEVCRLYPNVRFVVGGDGPKHVRLEEMREKHSLQDRVEMLGAV 265

  Fly   260 EHNRVRDFLVRGHIFLNTSLTEAYCMAIVEAASCGLQVVSTSVGGIPEVLPKSLILLAEPEIDAI 324
            .|:|||..||.||||||:|||||:|:||:|||||||..|||.|||:|||||..:::||||:.|.:
plant   266 PHSRVRSVLVTGHIFLNSSLTEAFCIAILEAASCGLLTVSTRVGGVPEVLPDDMVVLAEPDPDDM 330

  Fly   325 YAAILIAIDRHRKSSFKVSPSVGNGHLASDANGKVKRRRRRKVDTPISPTQLPAVSAPPADQNSS 389
            ..||..||                                                        |
plant   331 VRAIEKAI--------------------------------------------------------S 339

  Fly   390 TEPVMCPYRCNELVETLYNWEDVALRTVKVYDRVLNERSFTTSELVFAVWQHGSW----FLVFFV 450
            ..|.:.|...:..::.||:|:|||.||..||||.|...:.:..|.:......|:|    |.:..:
plant   340 ILPTINPEEMHNRMKKLYSWQDVAKRTEIVYDRALKCSNRSLLERLMRFLSCGAWAGKLFCMVMI 404

  Fly   451 VAHFLMRLLELWRPRKHVEIAQDV 474
            :.:.|.|||:|.:|.:.:|.|.|:
plant   405 LDYLLWRLLQLLQPDEDIEEAPDI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-A	NP_001286547.1	RfaB	1..309	CDD:223515	182/308 (59%)
PIG-A	NP_001286547.1	GT1_PIG-A_like	2..451	CDD:99970	214/453 (47%)
SETH2	NP_001326667.1	GT4_PIG-A-like	8..403	CDD:340827	214/451 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	163	1.000	Domainoid score	I1234
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1982
Inparanoid	1	1.050	403	1.000	Inparanoid score	I462
OMA	1	1.010	-	-		QHG53778
OrthoDB	1	1.010	-	-		D719531at2759
OrthoFinder	1	1.000	-	-		FOG0002788
OrthoInspector	1	1.000	-	-		oto3229
orthoMCL	1	0.900	-	-		OOG6_100580
Panther	1	1.100	-	-	LDO	PTHR45871
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3161
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840