DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-A and piga

DIOPT Version :9

Sequence 1:	NP_001286547.1	Gene:	PIG-A / 37020	FlyBaseID:	FBgn0034270	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_001119918.1	Gene:	piga / 791759	ZFINID:	ZDB-GENE-040426-1086	Length:	487	Species:	Danio rerio

Alignment Length:	478	Identity:	235/478 - (49%)
Similarity:	294/478 - (61%)	Gaps:	62/478 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ICMVSDFFYPSIGGVEEHVYNLSQMLLSLGHKIVVLTHAYGDCSGIRYVTGYLKVYYLPIKVCYN 67
            ||||||||||::||||.|:|.|||.|:..|||:|:.||||||..||||:|..|||||||::|.||
Zfish    39 ICMVSDFFYPNMGGVESHIYQLSQCLIEKGHKVVIATHAYGDRRGIRYLTNGLKVYYLPLQVMYN 103

  Fly    68 QCILPTAVCNVPMLRAVLLRERVEVVHGHSAFSALAHEALMVGSLLGLKTVFTDHSLFGFADLSA 132
            |....|...::|:||.:.:||.:.:||.||:|||:||:||.....:||.|||||||||||||||:
Zfish   104 QSTSTTCFHSLPLLRCIFVRECITIVHAHSSFSAMAHDALFHAKTMGLNTVFTDHSLFGFADLSS 168

  Fly   133 ALTNNLLEVNLGMVNHAICVSHIGKENTVLRARVAKHRVSVIPNAVDTALFTPDPQQRPSNDIIN 197
            .|||.||.|:|...||.:|||:..||||||||.:....|||||||||...|||||.:| .|..|.
Zfish   169 VLTNKLLTVSLCDTNHIVCVSYTSKENTVLRATLDPEIVSVIPNAVDPTDFTPDPCRR-DNSKIT 232

  Fly   198 IVVASRLVYRKGIDLLAGIIPRF-KNTPNINFIIVGDGPKRDLLEEIREKTNMQERVQMVGAVEH 261
            |||.||||||||||||:||||.. ...|::.|:|.|:||||.:|||:|||..:.:||:::||::|
Zfish   233 IVVISRLVYRKGIDLLSGIIPELCGRHPDLCFLIGGEGPKRIILEEVREKYQLHDRVRLLGALDH 297

  Fly   262 NRVRDFLVRGHIFLNTSLTEAYCMAIVEAASCGLQVVSTSVGGIPEVLPKSLILLAEPEIDAIYA 326
            ..|||.||:||||||||||||:||||||.||||||||||.|||||||||..|:.|..|.:.:
Zfish   298 KDVRDVLVQGHIFLNTSLTEAFCMAIVEGASCGLQVVSTRVGGIPEVLPNELVTLCGPSVCS--- 359

  Fly   327 AILIAIDRHRKSSFKVSPSVGNGHLASDANGKVKRRRRRKVDTPISPTQLPAVSAPPADQNSSTE 391
                                    |.......:|:.|...|::|.:
Zfish   360 ------------------------LCDGLETVIKKIRSGNVESPAA------------------- 381

  Fly   392 PVMCPYRCNELVETLYNWEDVALRTVKVYDRVLNERSFTTSELVFAVWQH-----GSWFLVFFVV 451
                   .:..|.|||.|.:||.||.|||:||..|.....|..:..:..|     ||.| .|..|
Zfish   382 -------IHRKVRTLYTWRNVAERTEKVYNRVCREPVLPLSARLHRLRSHCGAVAGSIF-SFVAV 438

  Fly   452 AHFLMRLLELW-RPRKHVEIAQD 473
            .:||..|...| ||...:::|.|
Zfish   439 INFLFLLFLQWLRPDSLIDVAVD 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-A	NP_001286547.1	RfaB	1..309	CDD:223515	194/306 (63%)
PIG-A	NP_001286547.1	GT1_PIG-A_like	2..451	CDD:99970	226/453 (50%)
piga	NP_001119918.1	GT1_PIG-A_like	38..437	CDD:99970	226/452 (50%)
piga	NP_001119918.1	RfaB	39..409	CDD:223515	219/423 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595496
Domainoid	1	1.000	159	1.000	Domainoid score	I4070
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1982
Inparanoid	1	1.050	411	1.000	Inparanoid score	I1827
OMA	1	1.010	-	-		QHG53778
OrthoDB	1	1.010	-	-		D305260at33208
OrthoFinder	1	1.000	-	-		FOG0002788
OrthoInspector	1	1.000	-	-		oto40304
orthoMCL	1	0.900	-	-		OOG6_100580
Panther	1	1.100	-	-	LDO	PTHR45871
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R517
SonicParanoid	1	1.000	-	-		X3161
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800