DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIG-A and gpi3

DIOPT Version :9

Sequence 1:	NP_001286547.1	Gene:	PIG-A / 37020	FlyBaseID:	FBgn0034270	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_595519.1	Gene:	gpi3 / 2540986	PomBaseID:	SPBC3D6.07	Length:	456	Species:	Schizosaccharomyces pombe

Alignment Length:	475	Identity:	202/475 - (42%)
Similarity:	275/475 - (57%)	Gaps:	62/475 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 MVSDFFYPSIGGVEEHVYNLSQMLLSLGHKIVVLTHAYGDCSGIRYVTGYLKVYYLPIKVCYNQC 69
            ||||||:|..||:|.|::.|||.|:.||||::|:||||.|..|:||:|..|.|||:|:...|.:.
pombe     1 MVSDFFFPQPGGIESHIFQLSQRLIDLGHKVIVITHAYKDRVGVRYLTNGLTVYYVPLHTVYRET 65

  Fly    70 ILPTAVCNVPMLRAVLLRERVEVVHGHSAFSALAHEALMVGSLLGLKTVFTDHSLFGFADLSAAL 134
            ..|:.....|:.|.:::||.:|:||||.:.|.|.|:|::....:||||.|||||||||||..:.:
pombe    66 TFPSFFSFFPIFRNIVIRENIEIVHGHGSLSFLCHDAILHARTMGLKTCFTDHSLFGFADAGSIV 130

  Fly   135 TNNLLEVNLGMVNHAICVSHIGKENTVLRARVAKHRVSVIPNAVDTALFTPDPQQRPSNDIINIV 199
            ||.||:..:..|||.|||||..:|||||||.:...||||||||:....|.||| .:.|.|.:.||
pombe   131 TNKLLKFTMSDVNHVICVSHTCRENTVLRAVLNPKRVSVIPNALVAENFQPDP-SKASKDFLTIV 194

  Fly   200 VASRLVYRKGIDLLAGIIPRF-KNTPNINFIIVGDGPKRDLLEEIREKTNMQERVQMVGAVEHNR 263
            |.|||.|.||||||..:|||. ...|.:.|:|.|||||...||::|||..:|:||:|:|:|.|::
pombe   195 VISRLYYNKGIDLLIAVIPRICAQHPKVRFVIAGDGPKSIDLEQMREKYMLQDRVEMLGSVRHDQ 259

  Fly   264 VRDFLVRGHIFLNTSLTEAYCMAIVEAASCGLQVVSTSVGGIPEVLPKSLILLAEPEIDAIYAAI 328
            |||.:|||||:|:.|||||:...:||||||||.|:||.|||:|||||..:...|.||.|.:
pombe   260 VRDVMVRGHIYLHPSLTEAFGTVLVEAASCGLYVISTKVGGVPEVLPSHMTRFARPEEDDL---- 320

  Fly   329 LIAIDRHRKSSFKVSPSVGNGHLASDANGKVKRRRRRKVDTPISPTQLPAVSAPPADQNSSTEPV 393
                                                  .||      |.:|.....|....||..
pombe   321 --------------------------------------ADT------LSSVITDYLDHKIKTETF 341

  Fly   394 MCPYRCNELVETLYNWEDVALRTVKVYDRVLNERSFTTSELVFAVWQHGSW----FLVFFVVAHF 454
                  :|.|:.:|:|.|||.||.||||.:.:|.:....:.:...:..|.|    |.:...:.:.
pombe   342 ------HEEVKQMYSWIDVAERTEKVYDSICSENNLRLIDRLKLYYGCGQWAGKLFCLLIAIDYL 400

  Fly   455 LMRLLE-LWRPRKHVEIAQD 473
            :|.||| :| |...::.|.|
pombe   401 VMVLLEWIW-PASDIDPAVD 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIG-A	NP_001286547.1	RfaB	1..309	CDD:223515	163/304 (54%)
PIG-A	NP_001286547.1	GT1_PIG-A_like	2..451	CDD:99970	194/450 (43%)
gpi3	NP_595519.1	GT1_PIG-A_like	1..395	CDD:99970	194/448 (43%)
gpi3	NP_595519.1	RfaB	1..369	CDD:223515	190/422 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	146	1.000	Domainoid score	I1140
eggNOG	1	0.900	-	-		E1_COG0438
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1982
Inparanoid	1	1.050	361	1.000	Inparanoid score	I459
OMA	1	1.010	-	-		QHG53778
OrthoFinder	1	1.000	-	-		FOG0002788
OrthoInspector	1	1.000	-	-		oto100580
orthoMCL	1	0.900	-	-		OOG6_100580
Panther	1	1.100	-	-	LDO	PTHR45871
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R517
SonicParanoid	1	1.000	-	-		X3161
TreeFam	1	0.960	-	-
	14	13.860