Protein Alignment ITK and Src64B

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_001286937.1
• Gene: Src64B / 48973
• FlyBaseID: FBgn0262733
• Length: 553
• Species: Drosophila melanogaster
• Alignment Length: 522
• Identity: 188/522 - (36%)
• Similarity: 274/522 - (52%)
• Gaps: 54/522 - (10%)

Human   106 LKEETRNNNSLVPKYHPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWE 170
            |.::..|..||..:|.|                        ||......|.......|..||...
  Fly    47 LGQKHNNGGSLDSRYTP------------------------DPNHRGPLKIGGKGGVDIIRPRTT 87

Human   171 PE-------ETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD-RNGHEGYVPSSYLV 227
            |.       :.||:|||||::.|..:|:..:.:...::|.:|..||||.: ....||.:|.:::.
  Fly    88 PTGVPGVVLKRVVVALYDYKSRDESDLSFMKGDRMEVIDDTESDWWRVVNLTTRQEGLIPLNFVA 152

Human   228 EKSPNNLETYEWYNKSISRDKAEKLLL-DTGKEGAFMVRDS-RTAGTYTVSVFTKAVVSENNPCI 290
            |:...|.|  :|:.:::.|.:|:|||| :....|.|:||.| .....|::||  |.........:
  Fly   153 EERSVNSE--DWFFENVLRKEADKLLLAEENPRGTFLVRPSEHNPNGYSLSV--KDWEDGRGYHV 213

Human   291 KHYHIKETNDNPKRYYVAEKYVFDSI-PLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAG--LR 352
            |||.||..::.  .||:|....|.|: .|::.|.:.|..||...|..| |...|......|  ||
  Fly   214 KHYRIKPLDNG--GYYIATNQTFPSLQALVMAYSKENALGLCHILSRP-CPKPQPQMWDLGPELR 275

Human   353 YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPK 417
             .|:.|..||:..::::|.|.||.|..|.|.|...||:||:|||.||...|::||.:|.|..|.:
  Fly   276 -DKYEIPRSEIQLLRKLGRGNFGEVFYGKWRNSIDVAVKTLREGTMSTAAFLQEAAIMKKFRHNR 339

Human   418 LVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFA-AETLLGMCLDVCEGMAYLEEACVIHR 481
            ||.||.||.::.||.:|.|:|..|.|.|:||...|.:. .|.|:.:...|..||.|||...:|||
  Fly   340 LVALYAVCSQEEPIYIVQEYMSKGSLLDFLREGDGRYLHFEDLIYIATQVASGMEYLESKQLIHR 404

Human   482 DLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGV 546
            ||||||.|:|||.|.|:.|||:.|.:.||:|....|::|||||.:||...:.::|.||||||:|:
  Fly   405 DLAARNVLIGENNVAKICDFGLARVIADDEYCPKQGSRFPVKWTAPEAIIYGKFSIKSDVWSYGI 469

Human   547 LMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTH-----VYQIMNHCWKERPEDRPAFS 606
            |:.|:|:.|::||....:.||:|:|..|||:.||   :.|     :||::..||...||.||.|.
  Fly   470 LLMELFTYGQVPYPGMHSREVIENIERGFRMPKP---TNHYFPDNIYQLLLQCWDAVPEKRPTFE 531

Human   607 RL 608
            .|
  Fly   532 FL 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	6/41 (15%)
		SH3_ITK	174..229	CDD:212841	18/55 (33%)
		SH2_Tec_Itk	232..340	CDD:198259	35/110 (32%)
		PTKc_Itk	358..613	CDD:133243	115/257 (45%)
Src64B	NP_001286937.1	SH2_Src_family	158..259	CDD:199827	34/106 (32%)
		PTKc_Src_like	289..538	CDD:270630	112/248 (45%)
		SH3_Src_like	99..150	CDD:212779	18/50 (36%)