Protein Alignment ITK and Abl

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Alignment Length: 461
• Identity: 172/461 - (37%)
• Similarity: 273/461 - (59%)
• Gaps: 31/461 - (6%)

Human   157 LPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRNGHEGY 220
            |.|.||::     :|:  :.:||||:|.....:|:|::.|:..:|..::. .|......:|:.|:
  Fly   198 LAPGPEED-----DPQ--LFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGW 255

Human   221 VPSSYLVEKSP-NNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVV 283
            |||:|:   :| |:||.:.||:..|||:.|| .||.:|..|:|:||:|.:: |..::|:..:..|
  Fly   256 VPSNYV---TPLNSLEKHSWYHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRV 316

Human   284 SENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQ--HNGGGLVTRLRYPVCFGRQKAP 346
                   .||.|.|..|.  :.:|.::..|:::..|:::|.  |.|.||:|.|.||.  .:|..|
  Fly   317 -------YHYRISEDPDG--KVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPA--PKQNKP 370

Human   347 VTAGL--RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIREGAMSEEDFIEEAE 408
            ....|  ...:|.|..:::....::|.||:|.|:...|.. .:.||:||::|..|:.:||:|||.
  Fly   371 TVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAA 435

Human   409 VMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAY 472
            :|.::.||.||||.|||..:.|..::.|||.||.|.|:||:. |....|..||.|...:..||:|
  Fly   436 IMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSY 500

Human   473 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS 537
            ||....|||||||||||||:|:::||:|||:.|.:.||.||:..|.|||:||.:||..:::::|:
  Fly   501 LESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFST 565

Human   538 KSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDR 602
            |||||:||||:||:.:.|..||.....::|...:..|:|:.:|......||.:|..||:....||
  Fly   566 KSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDR 630

Human   603 PAFSRL 608
            |.|..:
  Fly   631 PTFKSI 636

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841	16/55 (29%)
		SH2_Tec_Itk	232..340	CDD:198259	38/110 (35%)
		PTKc_Itk	358..613	CDD:133243	108/253 (43%)
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	16/56 (29%)
		SH2_ABL	268..363	CDD:198189	34/104 (33%)
		PTKc_Abl	382..644	CDD:270645	109/255 (43%)
		FABD	1584..1723	CDD:197885