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Protein Alignment ITK and Shark

DIOPT Version :10

Sequence 1:	NP_005537.3	Gene:	ITK / 3702	HGNCID:	6171	Length:	620	Species:	Homo sapiens
Sequence 2:	NP_524743.2	Gene:	Shark / 44353	FlyBaseID:	FBgn0015295	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	288	Identity:	103/288 - (35%)
Similarity:	156/288 - (54%)	Gaps:	30/288 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   339 CFGRQKAPVTAGLRYGK--WVIDPSELTFVQEIGSGQFGLVHLGYWLNKD--------KVAIKTI 393
            |.|....|....:...|  :.|:|.:|...:|||.|:||.||.|:.|.|.        :||||.:
  Fly   636 CSGTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSGWLLRKSGAGEESRLEVAIKML 700

Human   394 REGAMSEEDFIEEAEVMMKLSHPKLVQLYGVC--------LEQAPICLVFEF-MEHGCLSDYLRT 449
            .:...::::|:.||.|||:|.|..:|:|.|:.        .|.||:..:.:: ::||
  Fly   701 SDEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGEMLMMVQELAPLGSMLQYILDHG-------- 757

Human   450 QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL--DDQY 512
             ..:.|...|......:..||.|||....:||||||||.|:......|:|||||:|.:.  ..:|
  Fly   758 -HEITANAELKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEY 821

Human   513 TSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRL 577
            ..:.|.::|::|.:||.|:...:|..||||||||.:||:||.|..||...||.:.::.:.:|.||
  Fly   822 QFTQGGRWPIRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERL 886

Human   578 YKPRLASTHVYQIMNHCWKERPEDRPAF 605
            .:|.|...::|.:|..||||||:|||.|
  Fly   887 PQPNLCPAYIYAVMQSCWKERPKDRPTF 914

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.