Protein Alignment ITK and Ret

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Alignment Length: 297
• Identity: 102/297 - (34%)
• Similarity: 160/297 - (53%)
• Gaps: 28/297 - (9%)

Human   346 PVTAGLRY----GKWVIDPSELTFVQEIGSGQFGLVHLGYWL------NKDKVAIKTIREGAMSE 400
            |:.:|.|:    .||.....:|.....:|.|:||.|..|:..      ....||:|.:::|:.|.
  Fly   750 PLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSV 814

Human   401 E--DFIEEAEVMMKLSHPKLVQLYGVCL-EQAPICLVFEFMEHGCLSDYLRTQRGLFAA------ 456
            |  ..:.|.:::.::|||.:::|.|.|. .:||: |:.|:..:|.|..|||..|.:..|
  Fly   815 EYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPL-LIIEYARYGSLRSYLRLSRKIECAGVDFAD 878

Human   457 -------ETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVL-DDQYT 513
                   :.:|.....:|:|||||.|..::||||||||.|:.:.::.|:||||:||.|. ||.|.
  Fly   879 GVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYL 943

Human   514 SSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLY 578
            ..:..:.||||.:||..:...|:|||||||||||.||:.:.|..||...:...:...:.||:|:.
  Fly   944 KRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMD 1008

Human   579 KPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615
            :|...|..||.|:..||.:.|..||:|..|..:..::
  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKL 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841
		SH2_Tec_Itk	232..340	CDD:198259
		PTKc_Itk	358..613	CDD:133243	97/277 (35%)
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	97/277 (35%)