DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITK and Crk

DIOPT Version :10

Sequence 1:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens
Sequence 2:NP_651908.1 Gene:Crk / 43775 FlyBaseID:FBgn0024811 Length:271 Species:Drosophila melanogaster


Alignment Length:205 Identity:47/205 - (22%)
Similarity:80/205 - (39%) Gaps:58/205 - (28%)


- Green bases have known domain annotations that are detailed below.


Human   234 LETYE------WYNKSISRDKAEKLLLDTGKEGAFMVRDSRT-AGTYTVSVFTKAVVSENNPCIK 291
            ::|::      ||...:||..|.::|::..:.|.|:||||.: ||.|.:.|.....||       
  Fly     1 MDTFDVSDRNSWYFGPMSRQDATEVLMNERERGVFLVRDSNSIAGDYVLCVREDTKVS------- 58

Human   292 HYHIKETNDNPKRYYVAEKYVFDSIPLLINY---HQHNGGGLVTRLRYPVCFGRQKAPVTAGLRY 353
            :|.|.:.....:..|......||::|.|:.:   |..:    .|.|:.|.|...:|.       .
  Fly    59 NYIINKVQQQDQIVYRIGDQSFDNLPKLLTFYTLHYLD----TTPLKRPACRRVEKV-------I 112

Human   354 GKWVI---DPSELTFVQ-EI----------------GSGQFGLVHLGYWLNKDKVAIKTIREGAM 398
            ||:..   |..:|.|.: |:                .||:.|.:.:.|....|.          .
  Fly   113 GKFDFVGSDQDDLPFQRGEVLTIVRKDEDQWWTARNSSGKIGQIPVPYIQQYDD----------Y 167

Human   399 SEEDFIEEAE 408
            .:||.|::.|
  Fly   168 MDEDAIDKNE 177

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITKNP_005537.3 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841
SH2_Tec_Itk 232..340 CDD:198259 30/115 (26%)
PTKc_Itk 358..613 CDD:133243 13/71 (18%)
CrkNP_651908.1 SH2_CRK_like 4..108 CDD:198180 30/114 (26%)
SH3_CRK_N 109..163 CDD:212692 11/60 (18%)
SH3_CRK_C 201..257 CDD:212693
Blue background indicates that the domain is not in the aligned region.

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