Protein Alignment ITK and Cad96Ca

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_651349.1
• Gene: Cad96Ca / 43026
• FlyBaseID: FBgn0022800
• Length: 773
• Species: Drosophila melanogaster
• Alignment Length: 312
• Identity: 101/312 - (32%)
• Similarity: 155/312 - (49%)
• Gaps: 37/312 - (11%)

Human   337 PVCF----GRQKAPVTA---GLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYW------LNKDK- 387
            |.|.    |...||..|   .....:|......|.|...:|.|.||.|    |      :|.::
  Fly   437 PGCLTGGAGSSGAPENAFAGEANCDRWEFPRYRLKFFNILGEGAFGQV----WRCEATNINGNEG 497

Human   388 ---VAIKTIREGA--MSEEDFIEEAEVMMKLS-HPKLVQLYGVCLEQAPICLVFEFMEHGCLSDY 446
               ||:||::|.|  :..:|.:.|.|||..|. |..:|.|.|.|.::.|..::.|::..|.|..|
  Fly   498 ITTVAVKTLKESATEVDRKDLLSELEVMKSLEPHINVVHLLGCCTDKDPTFVILEYVNRGKLQTY 562

Human   447 LRTQR------------GLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVS 499
            ||:.|            .:..:..|......|.:||.||....:|||||||||.|:.::...||:
  Fly   563 LRSSRAERHYGNTHGKSNVLTSCDLTSFMYQVAKGMDYLTSRGIIHRDLAARNILITDDHTCKVA 627

Human   500 DFGMTRFVLDDQ-YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRS 563
            |||..|.|:..: |...:..|.|::|.:.|....:.:|.|||:||||:||||:.:.|..||...|
  Fly   628 DFGFARDVITSKIYERKSEGKLPIRWMATESLYDNIFSVKSDIWSFGILMWEIVTLGSTPYPGIS 692

Human   564 NSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615
            .::|:..:..|:||.||......:|.||.:||...|::||.|:.:::.|.::
  Fly   693 AADVMRKVRDGYRLEKPEHCRRELYNIMYYCWSHDPQERPLFAEIIQMLDKL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841
		SH2_Tec_Itk	232..340	CDD:198259	1/2 (50%)
		PTKc_Itk	358..613	CDD:133243	93/280 (33%)
Cad96Ca	NP_651349.1	Cadherin_repeat	65..164	CDD:206637
		PTKc	474..742	CDD:270623	91/271 (34%)