DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITK and htl

DIOPT Version :10

Sequence 1:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens
Sequence 2:NP_524394.2 Gene:htl / 42160 FlyBaseID:FBgn0010389 Length:729 Species:Drosophila melanogaster


Alignment Length:613 Identity:143/613 - (23%)
Similarity:240/613 - (39%) Gaps:165/613 - (26%)


- Green bases have known domain annotations that are detailed below.


Human    99 RQRWVLALKEETRNNNSLVPKYHPNFWMD-GKWRC--CSQLEKLATGCAQYDPTKNASKKPLPPT 160
            |.||.|.:::       |||.       | |.:.|  |:.|     ||.::|.....|.:.    
  Fly   154 RNRWTLTMED-------LVPG-------DCGNYTCKVCNSL-----GCIRHDTQVIVSDRV---- 195

Human   161 PEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEG--YVPS 223
               |.:|:              ....|..|.|..|      .:..:|...:.|....:.  :||.
  Fly   196 ---NHKPI--------------LMTGPLNLTLVVN------STGSMHCKYLSDLTSKKAWIFVPC 237

Human   224 SYLVEKSPNNLETYEWYNKSI---SRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSE 285
            ..:...|         .|:||   .:|:.:.:.:...:||.:...:|.:.|....:.:.:.|   
  Fly   238 HGMTNCS---------NNRSIIAEDKDQLDFVNVRMEQEGWYTCVESNSLGQSNSTAYLRVV--- 290

Human   286 NNPCIKHYHIKETN------DNPKRYYVAEKYVFDSI------PLLINY---------------- 322
                 :..|:.|..      .:....|:   :||..:      .|.:.|                
  Fly   291 -----RSLHVLEAGVASGSLHSTSFVYI---FVFGGLIFIFMTTLFVFYAIRKMKHEKVLKQRIE 347

Human   323 --HQ---------HNGGG-----------LVTRLR-----------YPVCFGRQKAPVTAGLRYG 354
              ||         ..|||           .|.|::           .|..|...:.|:.:     
  Fly   348 TVHQWTKKVIIFKPEGGGDSSGSMDTMIMPVVRIQKQRTTVLQNGNEPAPFNEYEFPLDS----- 407

Human   355 KWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEE--DFIEEAEVMMKLS-HP 416
            .|.:..|.|.....:|.|.||.|.:.. :|...||:|.::||...::  ..:.|.|||..:. |.
  Fly   408 NWELPRSHLVLGATLGEGAFGRVVMAE-VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHI 471

Human   417 KLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQR-------------------GLFAAETLLGM 462
            .::.|.|.|.:..|:.::.|:..||.|.|:|...|                   .:...:.|:..
  Fly   472 NIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQPPPSPPAHVITEKDLIKF 536

Human   463 CLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLD-DQYTSSTGTKFPVKWAS 526
            ...:..||.||.....|||||||||.||.::.|:|::|||:.|.:.. |.|..:|..:.|:||.:
  Fly   537 AHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMA 601

Human   527 PEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYEN-RSNSEVVEDISTGFRLYKPRLASTHVYQI 590
            ||......|.|||||||:|:|:||:.:.|:.||.. .|..|:...:.:|.|:.||...|.::|.:
  Fly   602 PESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYIL 666

Human   591 MNHCWKERPEDRPAFSRLLRQLAEIAES 618
            |..||....:|||.|:.::..:.::.::
  Fly   667 MRQCWHFNADDRPPFTEIVEYMDKLLQT 694

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITKNP_005537.3 PH_Btk 7..148 CDD:269944 14/51 (27%)
SH3_ITK 174..229 CDD:212841 8/56 (14%)
SH2_Tec_Itk 232..340 CDD:198259 24/171 (14%)
PTKc_Itk 358..613 CDD:133243 89/278 (32%)
htlNP_524394.2 Ig 101..191 CDD:472250 15/55 (27%)
Ig strand B 121..125 CDD:409353
Ig strand C 134..138 CDD:409353
Ig strand E 157..161 CDD:409353 2/3 (67%)
Ig strand F 171..176 CDD:409353 1/4 (25%)
Ig strand G 184..187 CDD:409353 0/2 (0%)
Ig 200..289 CDD:472250 17/117 (15%)
Ig strand B 216..220 CDD:409353 0/3 (0%)
Ig strand C 229..233 CDD:409353 0/3 (0%)
Ig strand E 255..259 CDD:409353 1/3 (33%)
Ig strand F 269..274 CDD:409353 0/4 (0%)
Ig strand G 282..285 CDD:409353 0/2 (0%)
Protein Kinases, catalytic domain 404..692 CDD:473864 91/293 (31%)
Blue background indicates that the domain is not in the aligned region.

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