Protein Alignment ITK and FER

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Alignment Length: 651
• Identity: 180/651 - (27%)
• Similarity: 291/651 - (44%)
• Gaps: 112/651 - (17%)

Human     3 NFILLEEQLIKKSQ--QKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEI 65
            |.||.|||..|::|  |...:|.|:..      |.:|.:...:.:..|.|...|...:...  .|
  Fly   727 NHILNEEQDAKRTQPSQHHHSSGSDCP------TNSSSSSSNNNNNNKNTSSNSNHSASQS--TI 783

Human    66 VKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKYHPNFWMDGKW 130
            :.|.|:.............:|..|....|..:.:.:   |::...|  :.|:     ||.:....
  Fly   784 ITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSK---AIRNTFR--SKLL-----NFQLKRSK 838

Human   131 RC--CSQLEKLATGCAQYD---------PTKNASKKPLPPTPEDNRRPLWEPEETVVIALY---- 180
            .|  |::..::....:.:|         |..:|:.:.....|...::|:   :.:|.|:.:
  Fly   839 PCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPV---KPSVQISGHKDHP 900

Human   181 ------DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPS-SYLVEKSPNN-LETY 237
                  :...|..:::.....||    ||:......::|   |...||| :..:..|.|. |...
  Fly   901 FESSSGELDENSDRDIDNDEEEE----DSASDDVLSMKD---HCYCVPSLAASISLSTNRPLYEE 958

Human   238 EWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCI--------KHYH 294
            ||::..:.|::..:||   ..:|.|:||::              :.:|.:..:        ||:.
  Fly   959 EWFHGVLPREEVVRLL---NNDGDFLVRET--------------IRNEESQIVLSVCWNGHKHFI 1006

Human   295 IKETNDNPKRYYVAEKYVFDSIPLLINYHQHN-------GGGLVTRLRYPVCFGRQKAPVTAGLR 352
            ::.|.:...|:   |...|.||..||.:..|:       .|.:   ||.|||..|
  Fly  1007 VQTTGEGNFRF---EGPPFASIQELIMHQYHSELPVTVKSGAI---LRRPVCRER---------- 1055

Human   353 YGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDK--VAIKTIREGAMSEE--DFIEEAEVMMKL 413
               |.:...::..::.||.|.||.|:... |...|  ||:||.|.....|:  .|::|..::.:.
  Fly  1056 ---WELSNDDVVLLERIGRGNFGDVYKAK-LKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY 1116

Human   414 SHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACV 478
            .||.:|:|.|:|:::.||.:|.|.:..|.|..|||...........:|||.|...||.|||....
  Fly  1117 DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNC 1181

Human   479 IHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTK-FPVKWASPEVFSFSRYSSKSDVW 542
            ||||||||||||.....:|:|||||:|  .:::|..|.|.| .||||.:||..:|.:|:|..|||
  Fly  1182 IHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244

Human   543 SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSR 607
            |:|:||||:||:|..||...:||...|.|.||:|:..|:.....:|::|..||....|.||.|..
  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309

Human   608 L 608
            :
  Fly  1310 I 1310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	27/153 (18%)
		SH3_ITK	174..229	CDD:212841	12/65 (18%)
		SH2_Tec_Itk	232..340	CDD:198259	28/123 (23%)
		PTKc_Itk	358..613	CDD:133243	102/256 (40%)
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	22/105 (21%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/247 (41%)