DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITK and Tak1

DIOPT Version :10

Sequence 1:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens
Sequence 2:NP_524080.1 Gene:Tak1 / 39659 FlyBaseID:FBgn0026323 Length:678 Species:Drosophila melanogaster


Alignment Length:274 Identity:82/274 - (29%)
Similarity:144/274 - (52%) Gaps:29/274 - (10%)


- Green bases have known domain annotations that are detailed below.


Human   358 IDPSELTFVQEIGSGQFGLVHLGYWLNKDK-VAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQL 421
            :|.||:|..:::|.|.:|:|....|  :|| ||:|.....| .::|..:|.:.:.::.||.::.|
  Fly    14 VDFSEITLREKVGHGSYGVVCKAVW--RDKLVAVKEFFASA-EQKDIEKEVKQLSRVKHPNIIAL 75

Human   422 YGVCLEQAPICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAYLEEAC---VIHRD 482
            :|:...|....|:.||.|.|.|.::|..: :..::....:.......||:|||....   :||||
  Fly    76 HGISSYQQATYLIMEFAEGGSLHNFLHGKVKPAYSLAHAMSWARQCAEGLAYLHAMTPKPLIHRD 140

Human   483 LAARNCLV---GENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSF 544
            :...|.|:   |.|  :|:.|||    .:.|:.|..|..:....|.:||||..|:|:.|.|::|:
  Fly   141 VKPLNLLLTNKGRN--LKICDFG----TVADKSTMMTNNRGSAAWMAPEVFEGSKYTEKCDIFSW 199

Human   545 GVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYK---PRLAST---HVYQIMNHCWKERPEDRP 603
            .:::|||.|. |.|::...|:..::     :::||   |.|.:|   .:..:|..|||..|||||
  Fly   200 AIVLWEVLSR-KQPFKGIDNAYTIQ-----WKIYKGERPPLLTTCPKRIEDLMTACWKTVPEDRP 258

Human   604 AFSRLLRQLAEIAE 617
            :...::..:.||.:
  Fly   259 SMQYIVGVMHEIVK 272

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITKNP_005537.3 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841
SH2_Tec_Itk 232..340 CDD:198259
PTKc_Itk 358..613 CDD:133243 80/268 (30%)
Tak1NP_524080.1 STKc_TAK1 25..275 CDD:270960 78/263 (30%)
Blue background indicates that the domain is not in the aligned region.

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