Protein Alignment ITK and Fak

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Alignment Length: 306
• Identity: 107/306 - (34%)
• Similarity: 152/306 - (49%)
• Gaps: 37/306 - (12%)

Human   341 GRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYW----LNKDK-------------- 387
            |....|........:.:|.||     .:||.||||.|::|.:    |.|.|
  Fly   440 GDYSTPTVRNYELDRALITPS-----AKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQR 499

Human   388 ----------VAIKTIREGAMSE--EDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEH 440
                      |||||.:.....|  |:|:.||.:|.|..||.:::|.|:| ...||.:|.|..:.
  Fly   500 NADSRPDVIQVAIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGIC-SVMPIWIVMELAKL 563

Human   441 GCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTR 505
            |.|..||:|.....:..|||..|..:...::|||....:|||:||||.||.....:|::|||::|
  Fly   564 GELRAYLKTNSERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSR 628

Human   506 FVLDDQYTSSTGT-KFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVE 569
            :|.|..|..||.| ..|:||.|||..:|.|:::.||||.|||.:||:...|..|::...||:|:.
  Fly   629 WVSDQSYYHSTPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVIL 693

Human   570 DISTGFRLYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEI 615
            .:..|.||..|......:|.:|:.||...|..||.|.|:...|.||
  Fly   694 KLENGERLPLPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEI 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841
		SH2_Tec_Itk	232..340	CDD:198259
		PTKc_Itk	358..613	CDD:133243	102/285 (36%)
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011
		PTKc_FAK	450..744	CDD:133187	105/296 (35%)
		Focal_AT	1250..1376	CDD:460992