DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITK and drk

DIOPT Version :10

Sequence 1:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens
Sequence 2:NP_476858.1 Gene:drk / 36497 FlyBaseID:FBgn0004638 Length:211 Species:Drosophila melanogaster


Alignment Length:152 Identity:43/152 - (28%)
Similarity:79/152 - (51%) Gaps:24/152 - (15%)


- Green bases have known domain annotations that are detailed below.


Human   177 IALYDYQTNDPQELALRRNEEYCLLD-SSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY 240
            ||.:|:......||:.|:.:...:|: ..:.:|:|. :.:|.||.:||:|:      .::.::||
  Fly     4 IAKHDFSATADDELSFRKTQILKILNMEDDSNWYRA-ELDGKEGLIPSNYI------EMKNHDWY 61

Human   241 NKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVVSENNPCIKHYHIKETNDNPKR 304
            ...|:|..||| ||....||||::|.|.:: |.:::||.....|.         |.|...|...:
  Fly    62 YGRITRADAEK-LLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQ---------HFKVLRDAQSK 116

Human   305 YYVAEKYV--FDSIPLLINYHQ 324
            :::   :|  |:|:..|:.||:
  Fly   117 FFL---WVVKFNSLNELVEYHR 135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITKNP_005537.3 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841 15/52 (29%)
SH2_Tec_Itk 232..340 CDD:198259 28/96 (29%)
PTKc_Itk 358..613 CDD:133243
drkNP_476858.1 SH3_GRB2_like_N 2..53 CDD:212738 14/49 (29%)
SH2_Grb2_like 56..149 CDD:199828 28/93 (30%)
SH3_GRB2_like_C 156..208 CDD:212739
Blue background indicates that the domain is not in the aligned region.

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