DRSC/TRiP Functional Genomics Resources

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Protein Alignment ITK and Src42A

DIOPT Version :10

Sequence 1:NP_005537.3 Gene:ITK / 3702 HGNCID:6171 Length:620 Species:Homo sapiens
Sequence 2:NP_001400996.1 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1606 Species:Drosophila melanogaster


Alignment Length:416 Identity:159/416 - (38%)
Similarity:242/416 - (58%) Gaps:36/416 - (8%)


- Green bases have known domain annotations that are detailed below.


Human   220 YVPSSYLVEKSPNNLETYEWYNKSISRDKAE-KLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAV 282
            :....:|.|||        ||.:.|.|.:|| ||||...:.|||::|||.:. ..|::||     
  Fly  1199 FTRGEFLNEKS--------WYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYSLSV----- 1250

Human   283 VSENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVC-------- 339
              .:...:|||.|::.::.  .:::|.:..|.::..|:.::..:..||...|..| |        
  Fly  1251 --RDGDTVKHYRIRQLDEG--GFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKP-CVQTNSFSG 1310

Human   340 -FGRQKAPVTAGLRY---GKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSE 400
             |..:| |||.||.:   .:|.||.:.|.||:::||||||.|..|.|.|...|||||::.|.|..
  Fly  1311 VFEIEK-PVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDP 1374

Human   401 EDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRG---LFAAETLLGM 462
            :||:.||::|.||.|.||:|||.||..:.||.::.|.|:||.|.:||:...|   ....:||:.|
  Fly  1375 KDFLAEAQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDM 1439

Human   463 CLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASP 527
            ...:..||||||....|||||||||.|||:..::|::|||:.|.:.:|:|.:..|.:||:||.:|
  Fly  1440 AAQIAAGMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAP 1504

Human   528 EVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMN 592
            |..::|::|.||||||||:|:.|:.:.|:|||...:|:||:..:..|:|:.:|......:|:||.
  Fly  1505 EAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIML 1569

Human   593 HCWKERPEDRPAFSRLLRQLAEIAES 618
            .||.:.|..||.|..|..:|.:...|
  Fly  1570 ECWHKDPMRRPTFETLQWKLEDFYTS 1595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ITKNP_005537.3 PH_Btk 7..148 CDD:269944
SH3_ITK 174..229 CDD:212841 1/8 (13%)
SH2_Tec_Itk 232..340 CDD:198259 31/118 (26%)
PTKc_Itk 358..613 CDD:133243 114/257 (44%)
Src42ANP_001400996.1 SH2_Src_Src42 1210..1301 CDD:198233 29/99 (29%)
PTKc_Frk_like 1328..1596 CDD:270653 117/268 (44%)
Blue background indicates that the domain is not in the aligned region.

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