Protein Alignment ITK and Btk

DIOPT Version :10

• Sequence 1: NP_005537.3
• Gene: ITK / 3702
• HGNCID: 6171
• Length: 620
• Species: Homo sapiens
• Sequence 2: NP_476745.1
• Gene: Btk / 34132
• FlyBaseID: FBgn0003502
• Length: 786
• Species: Drosophila melanogaster
• Alignment Length: 757
• Identity: 287/757 - (37%)
• Similarity: 400/757 - (52%)
• Gaps: 170/757 - (22%)

Human    11 LIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVE--IVKSDISIP 73
            ::|::|.|:|.:|.|:|.|:|.|||.:.:||:..:.::|..:|.|.|..::.||  .|..:...|
  Fly    48 MVKRAQNKKRFTPVNYKHRWFELTKRTFSYFDVENVERRRERGRIHLKGVRLVEEATVSGEGGDP 112

Human    74 -CHYKYPFQVVH---------------------------------DNYLLYVFAPDRESRQRWVL 104
             ....|||||.:                                 ..|.|||.|...:.|..|:.
  Fly   113 FAPDGYPFQVGYCEISASANSHQLENGNGGGSGVGIEGQQSGRAVPQYTLYVIANSEKERSEWIR 177

Human   105 ALKEETRNNNSLVPK---YHPNFWMDGKWRCCSQLEKLATGC---AQY-----------DPTKNA 152
            |:::...::|:  ||   |||..|...||.||..|.:...||   |.:           .|.:|:
  Fly   178 AIRQVCEDSNT--PKSYRYHPGLWSGKKWSCCKGLSRTTFGCRAAAHWREANNNPSNGSSPAQNS 240

Human   153 SKK-------------------------------------------------------------- 155
            ::.
  Fly   241 TRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGGGGGGGGSCTPTSLQPQSSLTTF 305

Human   156 ----------------------PLPPTP----EDNRRPLWEPEETVVIALYDYQTNDPQELALRR 194
                                  |.|.||    :||...:     .:|:|||.::..:..:|:|.:
  Fly   306 KQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFV-----KLVVALYPFKAIEGGDLSLEK 365

Human   195 NEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKE 259
            |.||.::|.|:.|||:|:|..|:.||:||:|:..|:...||.||||...:||.:||.||....||
  Fly   366 NAEYEVIDDSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEWYVGDMSRQRAESLLKQGDKE 430

Human   260 GAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETNDNPK-RYYVAEKYVFDSIPLLINYH 323
            |.|:||.|.|.|.||:|:.||...|.    :||||||:   |.: .||::||:..::||.|||||
  Fly   431 GCFVVRKSSTKGLYTLSLHTKVPQSH----VKHYHIKQ---NARCEYYLSEKHCCETIPDLINYH 488

Human   324 QHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLNKDKV 388
            :||.|||..||:...|  .:..|.||||.:.||.|.|.||..::|:||||||:|..|.|......
  Fly   489 RHNSGGLACRLKSSPC--DRPVPPTAGLSHDKWEIHPMELMLMEELGSGQFGVVRRGKWRGSIDT 551

Human   389 AIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGL 453
            |:|.::||.|||:||||||:||.||.||.||||||||.:..||.:|.|:|:||.|.:|||...
  Fly   552 AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIVTEYMKHGSLLNYLRRHE-- 614

Human   454 FAAETLLG-------MCLDVCEGMAYLEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQ 511
               :||:|       ||:.|.:||.|||....|||||||||||||...|:||:|||:.|:|||||
  Fly   615 ---KTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENVVKVADFGLARYVLDDQ 676

Human   512 YTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFR 576
            ||||.|||||:|||.|||.:::|:|||||||::||||||:|:.||:||....|:||||.:..|..
  Fly   677 YTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYGRLKNTEVVERVQRGII 741

Human   577 LYKPRLASTHVYQIMNHCWKERPEDRPAFSRLLRQLAEIAES 618
            |.||:..:..:|.:|..||...||:||||..|:.|||.:|::
  Fly   742 LEKPKSCAKEIYDVMKLCWSHGPEERPAFRVLMDQLALVAQT 783

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944	50/189 (26%)
		SH3_ITK	174..229	CDD:212841	22/54 (41%)
		SH2_Tec_Itk	232..340	CDD:198259	52/108 (48%)
		PTKc_Itk	358..613	CDD:133243	143/261 (55%)
Btk	NP_476745.1	PH_Btk	44..222	CDD:269944	49/175 (28%)
		SH3_Tec_like	346..399	CDD:212702	22/52 (42%)
		SH2_Tec_family	403..505	CDD:198188	53/110 (48%)
		PTKc_Tec_like	521..778	CDD:173637	143/261 (55%)